Nicole M André, Andrew D Miller and Gary R Whittaker
Original article on the portal www.ncbi.nlm.nih.gov
This work describes a cat with initial respiratory symptoms that preceded the development of fulminant feline infectious peritonitis (FIP) upon admission from the shelter. Histological examination of the tissues revealed typical lesions associated with FIP in the lungs, liver, colon, and small intestine. Histological examination of the nasal cavity revealed pyogranulomatous rhinitis. Immunohistochemistry with FIPV3-70 monoclonal antibody targeting FIP antigen in macrophages confirmed FIP and molecular analysis identified a spike protein mutation (R793S) consistent with the presence of FIP virus. Pathological changes, immunolabeling, and molecular analysis provide evidence that feline coronavirus respiratory infection is part of a range of FIP-related diseases.
Relevance and new information
This work emphasizes nasal pathology associated with FIP through a combination of histopathology, immunohistochemistry, and molecular characterization of the virus. Our work focuses on the relatively underestimated role of the airways in FIP.
Keywords: Infectious feline peritonitis, nasal cavity, rhinitis, feline coronavirus, spike protein
The whole work is published in English here.