Influence of surgical vs. of hormonal castration and routine vaccination for the treatment of FIP with GS441524 - NC Pedersen

Original article:

The problems associated with adverse sexual behavior in intact cats and males during GS treatment have caught my attention. The questions often come from countries where castration is either postponed or not part of common practice. There are also frequent questions about routine vaccinations. There are concerns that stress during castration / sterilization or vaccination may affect the outcome of GS-441524 treatment. I am convinced that such fears are exaggerated. If a cat is treated and in remission, or is considered cured, it can be neutered, but preferably in the least stressful way. Cats can be neutered and returned to their homes quickly and efficiently on the day of neutering with a minimum of preoperative, surgical and postoperative treatments and restrictions (eg caging, e-collars). Such surgeries will be less stressful for cats (and owners whose behavior is reflected back on their cats) than intolerable sexual behavior alone.

I am not in favor of hormonal treatment to prevent inappropriate sexual behavior in cats, and I think that effective castration will be less stressful in the long run than such prevention. Therefore, if a permanent change in this behavior is required, surgical castration is always better than chemical castration.

Is it better to neuter cats if they still have some part of the treatment in front of them, provided they look healthy and blood test results are normal? Yes, castration during treatment makes sense. However, we do not recommend unreasonable resumption of treatment during surgical castration during the 12-week observation period after the end of treatment, the so-called post-treatment. Castration is unlikely to change the fate of a cat with FIP, as the cure for FIP is given by the very cessation of treatment. The observation period is not intended to further improve, but only to confirm the cure.

Some owners of cured cats do not want their castration for breeding purposes. We know that genetic and environmental factors also affect FIP, which has led to the recommendation that purebred cats that give birth to kittens with FIP should not be used for breeding. This should be even more true for cats that have been cured of the FIP.

When it comes to vaccines, many already know that I am not a big supporter of vaccines for cats after reaching adulthood, nor of boosted vaccines in the first year. I also think that rabies vaccines are not justified for normal use in cats, neither in terms of public health nor in cats. Nevertheless, I am aware that these views are not generally accepted and that laws in some states require rabies vaccinations against cats. In any case, we did not notice any consequences of vaccination in any of our cured cats. However, this is not something I would recommend for cats in treatment. The immune system of these cats is responsible for other things than responding to the vaccine.

When are drugs other than GS-441524 indicated for the treatment of FIP? - NC Pedersen

There are often questions about the need for complementary medicines to GS-441524. Initially, supportive (symptomatic) treatment may be needed to keep cats alive long enough for the antiviral effect to take effect. Drugs often used in this early stage usually include antibiotics (doxycycline / clindamycin), analgesics (opioids, gabapentin), anti-inflammatory drugs (corticosteroids, NSAIDS), immunostimulants (interferons, non-specific immunostimulants) and fluids. I have tried to avoid excessive use of these drugs, except for their temporary use, and only if there are legitimate reasons for their use, especially in severely ill cats during the first few days. The most important goal of FIP treatment is to stop the replication of the virus in macrophages, which immediately stops the production of numerous inflammatory and immunosuppressive cytokines that cause the symptoms of FIP. While some drugs, such as corticosteroids (prednisolone) or NSAIDS (meloxicam), can inhibit inflammatory cytokines, the only drugs that completely inhibit these harmful cytokines are antivirals, such as GS-441524 or GC376. These drugs lead to a dramatic improvement in fever, activity, appetite, etc. within 24-48 hours. This improvement will be much more pronounced than with any other medicine. Therefore, unless there are reasons to take other medicines, they should be discontinued as soon as there is a significant and stable improvement in FIP symptoms. I'm not even a supporter of the supplements that cats often take during treatment. B12 only treats B12 deficiency, not FIP anemia. This also applies to a wide range of nutritional supplements and many types of special cat food. Follow the proven commercial brands of cat food supplemented with animal meat.

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