{"id":4122,"date":"2021-01-10T23:52:43","date_gmt":"2021-01-10T22:52:43","guid":{"rendered":"https:\/\/www.fipwarriors.eu\/?page_id=4122"},"modified":"2021-09-15T07:14:42","modified_gmt":"2021-09-15T05:14:42","slug":"remdesivir","status":"publish","type":"page","link":"https:\/\/www.fipwarriors.eu\/en\/remdesivir\/","title":{"rendered":"Remdesivir"},"content":{"rendered":"<div class=\"wp-block-media-text alignwide has-media-on-the-right is-stacked-on-mobile is-vertically-aligned-top\" style=\"grid-template-columns:auto 33%\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"310\" height=\"486\" src=\"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/09\/Remdesivir_500.gif\" alt=\"\" class=\"wp-image-8505 size-full\"\/><\/figure><div class=\"wp-block-media-text__content\">\n<ul class=\"wp-block-list\"><li>Molekulov&yacute; vzorec:  C<sub>27<\/sub>H<sub>35<\/sub>N<sub>6<\/sub>O<sub>8<\/sub>P<\/li><li><a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemBody&gt;&amp;lt;b&amp;gt;Registra&#269;n&eacute; &#269;&iacute;slo CAS&amp;lt;\/b&amp;gt;&amp;amp;nbsp;je jednozna&#269;n&yacute; numerick&yacute; identifik&aacute;tor, pou&#382;&iacute;van&yacute; v ch&eacute;mii pre chemick&eacute; l&aacute;tky,&amp;amp;nbsp;polym&eacute;ry, biologick&eacute; sekvencie,&amp;amp;nbsp;zmesi&amp;amp;nbsp;a zliatiny. Bolo zaveden&eacute; redakciou svetovo najroz&scaron;&iacute;renej&scaron;ieho chemick&eacute;ho refer&aacute;tov&eacute;ho &#269;asopisu&amp;amp;nbsp;&amp;lt;i&amp;gt;Chemical Abstracts&amp;lt;\/i&amp;gt;, vyd&aacute;van&eacute;ho Americkou chemickou spolo&#269;nos&#357;ou (&amp;lt;i&amp;gt;American Chemical Society&amp;lt;\/i&amp;gt;).&amp;amp;nbsp;&amp;lt;i&amp;gt;Chemical Abtracts Service&amp;lt;\/i&amp;gt;&amp;amp;nbsp;udr&#382;uje datab&aacute;zu chemick&yacute;ch zl&uacute;&#269;en&iacute;n pop&iacute;san&yacute;ch vo vedeckej literat&uacute;re, v patentoch a v in&yacute;ch publik&aacute;ciach (tzv.&amp;amp;nbsp;&amp;lt;i&amp;gt;CAS registry&amp;lt;\/i&amp;gt;). V s&uacute;&#269;asnej dobe t&aacute;to datab&aacute;za obsahuje pribli&#382;ne 23 mili&oacute;nov zl&uacute;&#269;en&iacute;n a denne ich prib&uacute;da v priemere 4-tis&iacute;c. Datab&aacute;za je tie&#382; najautoritat&iacute;vnej&scaron;&iacute;m zdrojom inform&aacute;cii o anglick&yacute;ch n&aacute;zvoch zl&uacute;&#269;en&iacute;n. Preto prakticky v&scaron;etky &scaron;pecializovan&eacute; chemick&eacute; datab&aacute;zy pri identifik&aacute;cii zl&uacute;&#269;en&iacute;n pou&#382;&iacute;vaj&uacute; toto registra&#269;n&eacute; &#269;&iacute;slo ako jeden z vyh&#318;ad&aacute;vac&iacute;ch prvkov.&#268;&iacute;slo je rozdelen&eacute; poml&#269;kami do troch z&oacute;n, kde prv&aacute; z&oacute;na m&aacute; premenn&yacute; po&#269;et &#269;&iacute;slic, &#271;al&scaron;ia m&aacute; v&#382;dy pr&aacute;ve dve &#269;&iacute;slice a posledn&aacute; z&oacute;na obsahuje jedin&uacute; &#269;&iacute;slicu, ktor&aacute; sl&uacute;&#382;i ako kontroln&yacute; s&uacute;&#269;et pre umo&#382;nenie automatickej kontroly spr&aacute;vnosti z&aacute;pisu registra&#269;n&eacute;ho &#269;&iacute;sla&lt;\/div&gt;\" href=\"https:\/\/www.fipwarriors.eu\/en\/glossary\/cas\/\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">CAS<\/a>#  1809249-37-3 <\/li><li><a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemBody&gt;&amp;lt;strong&amp;gt;Molekulov&aacute; hmotnos&#357;&amp;lt;\/strong&amp;gt;&nbsp; je s&uacute;&#269;et at&oacute;mov&yacute;ch hmotnost&iacute; at&oacute;mov danej molekuly.&lt;\/div&gt;\" href=\"https:\/\/www.fipwarriors.eu\/en\/glossary\/molarna-hmotnost\/\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">Molekulov&aacute; hmotnos&#357;<\/a>:   602.576 <\/li><li>2-ethylbutyl-(2S)-2-{[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-kyanoxolan-2-yl]methoxy}(fenoxy)fosforyl]amino}propano&aacute;t<\/li><li>Synonymum:  GS-5734<\/li><li>Obchodn&yacute; n&aacute;zov: Veklury <\/li><li>GS-441524 prodrug<\/li><li>Patent# <a href=\"https:\/\/patents.google.com\/patent\/WO2009132135A1\/en\" target=\"_blank\" rel=\"noreferrer noopener\">US-2020276219-A1<\/a>, <a href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/patent\/CN-111093627-A\" target=\"_blank\" rel=\"noreferrer noopener\">CN-111093627-A<\/a>, <a href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/121304016#section=Depositor-Supplied-Patent-Identifiers&amp;fullscreen=true\" target=\"_blank\" rel=\"noreferrer noopener\">at&#271;&hellip;<\/a><br>Vlastn&iacute;k: <a rel=\"noreferrer noopener\" href=\"https:\/\/cs.wikipedia.org\/wiki\/Gilead_Sciences\" target=\"_blank\">Gilead Sciences , Inc<\/a>  <\/li><li><a href=\"https:\/\/www.chemsrc.com\/en\/cas\/1809249-37-3_1491289.html\" target=\"_blank\" rel=\"noreferrer noopener\">ChemSrc<\/a>, <a href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/121304016\" target=\"_blank\" rel=\"noreferrer noopener\">PubChem<\/a><\/li><\/ul>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Remdesivir je experiment&aacute;lne antivirotikum &ndash; adenoz&iacute;nov&yacute; anal&oacute;g. Vyvinula ho americk&aacute; spolo&#269;nos&#357; Gilead Sciences na lie&#269;bu infekci&iacute; sp&ocirc;soben&yacute;ch v&iacute;rusmi Ebola a Marburg. Uk&aacute;zal sa v&scaron;ak by&#357; &uacute;&#269;inn&yacute; aj proti in&yacute;m <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemBody&gt;Ribonukleov&aacute; kyselina. Polymern&iacute; makromolekula, jej&iacute;&#382; z&aacute;kladn&iacute;mi stavebn&iacute;mi jednotkami jsou ribonukleotidy. Je sou&#269;&aacute;st&iacute; v&scaron;ech bun&#283;k a slou&#382;&iacute; k p&#345;enosu informac&iacute; z DNA d&aacute;le do bu&#328;ky. Existuje mnoho druh&#367; RNA s r&#367;zn&yacute;mi funkcemi. Mezi nejzn&aacute;mn&#283;j&scaron;&iacute; pat&#345;&iacute; mRNA (medi&aacute;torov&aacute;), tRNA (transferov&aacute;) a rRNA (ribozom&aacute;ln&iacute;).&lt;\/div&gt;\" href=\"https:\/\/www.fipwarriors.eu\/en\/glossary\/rna\/\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">RNA<\/a> v&iacute;rusom vr&aacute;tane koronav&iacute;rusov. Overuje sa tie&#382; jeho &uacute;&#269;innos&#357; proti ochoreniu covid-19. V novembri 2020 Svetov&aacute; zdravotn&iacute;cka organiz&aacute;cia vo svojom stanovisku neodporu&#269;ila jeho pou&#382;itie ako lieku proti tomuto ochoreniu, lebo ch&yacute;bali ak&eacute;ko&#318;vek d&ocirc;kazy, &#382;e liek zvy&scaron;uje &scaron;ance na pre&#382;itie pacientov s touto chorobou, &#269;i &#382;e u nich zni&#382;uje potrebu p&#318;&uacute;cnej ventil&aacute;cie.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Mechanizmus &uacute;&#269;inku<\/h3>\n\n\n\n<div class=\"wp-block-image lm-center\"><figure class=\"alignright size-full is-resized\"><a href=\"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/09\/remdesivir-product-invivogen-SK-1.jpg\"><img decoding=\"async\" src=\"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/09\/remdesivir-product-invivogen-SK-1.jpg\" alt=\"\" class=\"wp-image-8524\" width=\"500\" srcset=\"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/09\/remdesivir-product-invivogen-SK-1.jpg 623w, https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/09\/remdesivir-product-invivogen-SK-1-284x300.jpg 284w, https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/09\/remdesivir-product-invivogen-SK-1-11x12.jpg 11w, https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/09\/remdesivir-product-invivogen-SK-1-350x369.jpg 350w, https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/09\/remdesivir-product-invivogen-SK-1-64x67.jpg 64w\" sizes=\"(max-width: 623px) 100vw, 623px\"\/><\/a><figcaption>Mechanizmus &uacute;&#269;inku remdesiviru<\/figcaption><\/figure><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Remdesivir &scaron;pecificky inhibuje aktivitu v&iacute;rusovej RNA-dependentnej RNA-polymer&aacute;zy (RdRp), nevyhnutnej pri replik&aacute;cii v&iacute;rusu <sup>[3-5]<\/sup>. Po vstupe do bunky je Remdesivir r&yacute;chlo metabolizovan&yacute; na nukleozidov&yacute; monofosf&aacute;t (GS-441542 MP), ktor&yacute; je &#271;alej transformovan&yacute; na akt&iacute;vnu trifosf&aacute;tov&uacute; formu (GS-441524). GS-441524 je adenoz&iacute;nov&yacute; trifosf&aacute;tov&yacute; anal&oacute;g (ATP), ktor&yacute; potom sl&uacute;&#382;i ako n&aacute;hradn&yacute; substr&aacute;t pre RdRp. GS-441524 sa za&#269;len&iacute; do novo syntetizovan&eacute;ho re&#357;azca RNA, &#269;o v kone&#269;nom d&ocirc;sledku sp&ocirc;sobuje pred&#269;asn&eacute; ukon&#269;enie produktu RNA. Na rozdiel od klasick&yacute;ch termin&aacute;torov re&#357;azcov v&scaron;ak za&#269;lenenie GS-441524 sp&ocirc;sobuje oneskoren&eacute; ukon&#269;enie re&#357;azca za t&yacute;mto miestom &ndash; umo&#382;&#328;uje pridanie 3 dal&scaron;&iacute;ch nukleotidov, k&yacute;m sa synt&eacute;za RNA zastav&iacute; <sup>[3, 4]<\/sup>. D&ocirc;le&#382;it&eacute; zistenie je, &#382;e GS-441524 sa vyh&yacute;ba korekt&uacute;re v&iacute;rusovou exoribonukle&aacute;zou (ExoN) <sup>[5]<\/sup>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Pou&#382;itie remdesiviru pre lie&#269;bu <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemBody&gt;Infek&#269;n&aacute; peritonit&iacute;da ma&#269;iek (angl. Feline infectious peritonitis, zau&#382;&iacute;van&aacute; skratka FIP) je infek&#269;n&eacute; ochorenie ma&#269;iek sp&ocirc;sobuj&uacute;ce smr&#357;. N&aacute;zov je mierne zav&aacute;dzaj&uacute;ci, preto&#382;e nejde o z&aacute;pal pobru&scaron;nice (&#269;i&#382;e peritonea), ale o z&aacute;pal ciev (vaskulit&iacute;da). Klinick&eacute; pr&iacute;znaky FIP sa v&scaron;ak &#269;asto prejavuj&uacute; vo forme z&aacute;palu pobru&scaron;nice. V&iacute;rus FIP nap&aacute;da v&scaron;ak aj pohrudnicu &ndash; z toho d&ocirc;vodu je niekedy choroba ozna&#269;ovan&aacute; tie&#382; ako Infek&#269;n&aacute; ma&#269;acia polyserozit&iacute;da (Feline infectious polyserositis).&lt;\/div&gt;\" href=\"https:\/\/www.fipwarriors.eu\/en\/glossary\/fip\/\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">FIP<\/a><\/h3>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"alignright size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/09\/bova-remdesivir.jpg\" alt=\"\" class=\"wp-image-8510\" width=\"448\" height=\"335\" srcset=\"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/09\/bova-remdesivir.jpg 1024w, https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/09\/bova-remdesivir-300x225.jpg 300w, https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/09\/bova-remdesivir-768x576.jpg 768w, https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/09\/bova-remdesivir-16x12.jpg 16w, https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/09\/bova-remdesivir-350x263.jpg 350w, https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/09\/bova-remdesivir-64x48.jpg 64w\" sizes=\"auto, (max-width: 448px) 100vw, 448px\"\/><figcaption>Remdesivir spolo&#269;nosti Bova &ndash; koncentr&aacute;cia 10mg\/ml.<\/figcaption><\/figure><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Pre leg&aacute;lne veterin&aacute;rne pou&#382;itie vyr&aacute;ba remdesivir spolo&#269;nos&#357; <a href=\"https:\/\/bova.co.uk\/\" target=\"_blank\" rel=\"noreferrer noopener\">Bova <\/a>v koncentr&aacute;cii 10mg\/ml vo vialk&aacute;ch s objemom 10ml.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Pre v&aacute;&#382;ne pr&iacute;pady FIP  je mo&#382;n&aacute; na za&#269;iatku lie&#269;by aj intraven&oacute;zna aplik&aacute;cia. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&Uacute;spe&scaron;nos&#357; lie&#269;by FIP je cca 85-90%.<\/p>\n\n\n\n<figure class=\"wp-block-table lm-small is-style-stripes\"><table><thead><tr><th>Vlhk&aacute;\/Such&aacute; FIP<\/th><th>Okul&aacute;rna FIP<\/th><th>Neurologick&aacute; FIP<\/th><\/tr><\/thead><tbody><tr><td>7-8 mg\/kg<\/td><td>10 mg\/kg<\/td><td>12-15 mg\/kg<\/td><\/tr><\/tbody><\/table><figcaption>D&aacute;vkovanie remdesiviru pri lie&#269;be FIP pod&#318;a sk&uacute;senost&iacute; z Austr&aacute;lie a UK<\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Referencie<\/h2>\n\n\n\n<ol class=\"has-small-font-size wp-block-list\"><li><strong>Warren, T.K.&nbsp;<em>et al<\/em>. 2016.<\/strong>&nbsp;Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature 531, 381-385.<\/li><li><strong>Gordon, C.J.&nbsp;<em>et al<\/em>. 2020.<\/strong>&nbsp;The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus. J Biol Chem<\/li><li><strong>Gordon, C.J.<em>&nbsp;et al.<\/em>&nbsp;2020.<\/strong>&nbsp;Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency. J Biol Chem 295, 6785-6797.<\/li><li><strong>Tchesnokov, E.P.&nbsp;<em>et al<\/em>. 2019.<\/strong>&nbsp;Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir. Viruses 11<\/li><li><strong>Agostini, M.L.&nbsp;<em>et al<\/em>. 2018.<\/strong>&nbsp;Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. mBio 9<\/li><li>Remdesivir na <a href=\"https:\/\/cs.wikipedia.org\/wiki\/Remdesivir\" target=\"_blank\" rel=\"noreferrer noopener\">&#269;eskej Wiki<\/a><\/li><li><a href=\"https:\/\/www.fipwarriors.eu\/liecba-fip-remdesivirom\/\" target=\"_blank\" rel=\"noreferrer noopener\">Lie&#269;ba FIP remdesivirom<\/a><\/li><\/ol>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Molekulov&yacute; vzorec: C27H35N6O8P CAS# 1809249-37-3 Molekulov&aacute; hmotnos&#357;: 602.576 2-ethylbutyl-(2S)-2-{[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-kyanoxolan-2-yl]methoxy}(fenoxy)fosforyl]amino}propano&aacute;t Synonymum: GS-5734 Obchodn&yacute; n&aacute;zov: Veklury GS-441524 prodrug Patent# US-2020276219-A1, CN-111093627-A, at&#271;&hellip;Vlastn&iacute;k: Gilead Sciences , Inc ChemSrc, PubChem Remdesivir je experiment&aacute;lne antivirotikum &ndash; adenoz&iacute;nov&yacute; anal&oacute;g. Vyvinula ho americk&aacute; spolo&#269;nos&#357; Gilead Sciences na lie&#269;bu infekci&iacute; sp&ocirc;soben&yacute;ch v&iacute;rusmi Ebola a Marburg. Uk&aacute;zal sa v&scaron;ak by&#357; &uacute;&#269;inn&yacute; aj proti in&yacute;m &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.fipwarriors.eu\/en\/remdesivir\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &quot;Remdesivir&quot;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":8285,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_uag_custom_page_level_css":"","footnotes":""},"categories":[],"tags":[],"class_list":["post-4122","page","type-page","status-publish","has-post-thumbnail","hentry"],"featured_image_urls_v2":{"full":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/08\/remdesivirFHDb.jpg",1920,1080,false],"thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/08\/remdesivirFHDb-150x150.jpg",150,150,true],"medium":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/08\/remdesivirFHDb-300x169.jpg",300,169,true],"medium_large":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/08\/remdesivirFHDb-768x432.jpg",525,295,true],"large":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/08\/remdesivirFHDb-1024x576.jpg",525,295,true],"1536x1536":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/08\/remdesivirFHDb-1536x864.jpg",1536,864,true],"2048x2048":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/08\/remdesivirFHDb.jpg",1920,1080,false],"trp-custom-language-flag":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/08\/remdesivirFHDb-18x10.jpg",18,10,true],"twentyseventeen-featured-image":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/08\/remdesivirFHDb.jpg",1920,1080,false],"twentyseventeen-thumbnail-avatar":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/08\/remdesivirFHDb-100x100.jpg",100,100,true],"woocommerce_thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/08\/remdesivirFHDb-250x250.jpg",250,250,true],"woocommerce_single":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/08\/remdesivirFHDb-350x197.jpg",350,197,true],"woocommerce_gallery_thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/08\/remdesivirFHDb-100x100.jpg",100,100,true]},"post_excerpt_stackable_v2":"<p>Molekulov&yacute; vzorec: C27H35N6O8PCAS# 1809249-37-3 <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemBody&gt;&amp;lt;strong&amp;gt;Molekulov&aacute; hmotnos&#357;&amp;lt;\/strong&amp;gt;&nbsp; je s&uacute;&#269;et at&oacute;mov&yacute;ch hmotnost&iacute; at&oacute;mov danej molekuly.&lt;\/div&gt;\" href=\"https:\/\/www.fipwarriors.eu\/en\/glossary\/molarna-hmotnost\/\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">Molekulov&aacute; hmotnos&#357;<\/a>: 602.576 2-ethylbutyl-(2S)-2-{[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-kyanoxolan-2-yl]methoxy}(fenoxy)fosforyl]amino}propano&aacute;tSynonymum: GS-5734Obchodn&yacute; n&aacute;zov: Veklury GS-441524 prodrugPatent# US-2020276219-A1, CN-111093627-A, at&#271;&hellip;Vlastn&iacute;k: Gilead Sciences , Inc ChemSrc, PubChem Remdesivir je experiment&aacute;lne antivirotikum &ndash; adenoz&iacute;nov&yacute; anal&oacute;g. Vyvinula ho americk&aacute; spolo&#269;nos&#357; Gilead Sciences na lie&#269;bu infekci&iacute; sp&ocirc;soben&yacute;ch v&iacute;rusmi Ebola a Marburg. Uk&aacute;zal sa v&scaron;ak by&#357; &uacute;&#269;inn&yacute; aj proti in&yacute;m RNA v&iacute;rusom vr&aacute;tane koronav&iacute;rusov. Overuje sa tie&#382; jeho &uacute;&#269;innos&#357; proti ochoreniu covid-19. V novembri 2020 Svetov&aacute; zdravotn&iacute;cka organiz&aacute;cia vo svojom stanovisku neodporu&#269;ila jeho pou&#382;itie ako lieku proti tomuto ochoreniu, lebo ch&yacute;bali ak&eacute;ko&#318;vek d&ocirc;kazy, &#382;e liek zvy&scaron;uje &scaron;ance na pre&#382;itie pacientov s touto chorobou, &#269;i &#382;e u nich zni&#382;uje potrebu&hellip;<\/p>\n","category_list_v2":"Uncategorised","author_info_v2":{"name":"LM","url":"https:\/\/www.fipwarriors.eu\/en\/author\/starman\/"},"comments_num_v2":"0 comments","featured_image_src":"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/08\/remdesivirFHDb.jpg","yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Remdesivir - FIP Warriors CZ\/SK \u00ae<\/title>\n<meta name=\"description\" content=\"Remdesivir je experiment\u00e1lne antivirotikum, ktor\u00e9 \u00fa\u010dinkuje ako anal\u00f3g adenoz\u00ednu. 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