{"id":8119,"date":"2021-08-01T23:42:25","date_gmt":"2021-08-01T21:42:25","guid":{"rendered":"https:\/\/www.fipwarriors.eu\/?page_id=8119"},"modified":"2025-07-24T15:49:30","modified_gmt":"2025-07-24T13:49:30","slug":"eidd-2801-molnupiravir","status":"publish","type":"page","link":"https:\/\/www.fipwarriors.eu\/en\/eidd-2801-molnupiravir\/","title":{"rendered":"EIDD-2801 (Molnupiravir)"},"content":{"rendered":"<div class=\"wp-block-media-text alignwide has-media-on-the-right is-stacked-on-mobile is-vertically-aligned-top\" style=\"grid-template-columns:auto 33%\"><div class=\"wp-block-media-text__content\">\n<ul class=\"wp-block-list\">\n<li>Molekulov&yacute; vzorec:   C<sub>13<\/sub>H<sub>19<\/sub>N<sub>3<\/sub>O<sub>7<\/sub> <\/li>\n\n\n\n<li><a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemBody&gt;&amp;lt;b&amp;gt;Registra&#269;n&eacute; &#269;&iacute;slo CAS&amp;lt;\/b&amp;gt;&amp;amp;nbsp;je jednozna&#269;n&yacute; numerick&yacute; identifik&aacute;tor, pou&#382;&iacute;van&yacute; v ch&eacute;mii pre chemick&eacute; l&aacute;tky,&amp;amp;nbsp;polym&eacute;ry, biologick&eacute; sekvencie,&amp;amp;nbsp;zmesi&amp;amp;nbsp;a zliatiny. Bolo zaveden&eacute; redakciou svetovo najroz&scaron;&iacute;renej&scaron;ieho chemick&eacute;ho refer&aacute;tov&eacute;ho &#269;asopisu&amp;amp;nbsp;&amp;lt;i&amp;gt;Chemical Abstracts&amp;lt;\/i&amp;gt;, vyd&aacute;van&eacute;ho Americkou chemickou spolo&#269;nos&#357;ou (&amp;lt;i&amp;gt;American Chemical Society&amp;lt;\/i&amp;gt;).&amp;amp;nbsp;&amp;lt;i&amp;gt;Chemical Abtracts Service&amp;lt;\/i&amp;gt;&amp;amp;nbsp;udr&#382;uje datab&aacute;zu chemick&yacute;ch zl&uacute;&#269;en&iacute;n pop&iacute;san&yacute;ch vo vedeckej literat&uacute;re, v patentoch a v in&yacute;ch publik&aacute;ciach (tzv.&amp;amp;nbsp;&amp;lt;i&amp;gt;CAS registry&amp;lt;\/i&amp;gt;). V s&uacute;&#269;asnej dobe t&aacute;to datab&aacute;za obsahuje pribli&#382;ne 23 mili&oacute;nov zl&uacute;&#269;en&iacute;n a denne ich prib&uacute;da v priemere 4-tis&iacute;c. Datab&aacute;za je tie&#382; najautoritat&iacute;vnej&scaron;&iacute;m zdrojom inform&aacute;cii o anglick&yacute;ch n&aacute;zvoch zl&uacute;&#269;en&iacute;n. Preto prakticky v&scaron;etky &scaron;pecializovan&eacute; chemick&eacute; datab&aacute;zy pri identifik&aacute;cii zl&uacute;&#269;en&iacute;n pou&#382;&iacute;vaj&uacute; toto registra&#269;n&eacute; &#269;&iacute;slo ako jeden z vyh&#318;ad&aacute;vac&iacute;ch prvkov.&#268;&iacute;slo je rozdelen&eacute; poml&#269;kami do troch z&oacute;n, kde prv&aacute; z&oacute;na m&aacute; premenn&yacute; po&#269;et &#269;&iacute;slic, &#271;al&scaron;ia m&aacute; v&#382;dy pr&aacute;ve dve &#269;&iacute;slice a posledn&aacute; z&oacute;na obsahuje jedin&uacute; &#269;&iacute;slicu, ktor&aacute; sl&uacute;&#382;i ako kontroln&yacute; s&uacute;&#269;et pre umo&#382;nenie automatickej kontroly spr&aacute;vnosti z&aacute;pisu registra&#269;n&eacute;ho &#269;&iacute;sla&lt;\/div&gt;\" href=\"https:\/\/www.fipwarriors.eu\/en\/glossary\/cas\/\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">CAS<\/a>#  <a href=\"https:\/\/www.chemsrc.com\/en\/baike\/1564121.html\" target=\"_blank\" rel=\"noreferrer noopener\">2349386-89-4<\/a><\/li>\n\n\n\n<li><a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemBody&gt;&amp;lt;strong&amp;gt;Molekulov&aacute; hmotnos&#357;&amp;lt;\/strong&amp;gt;&nbsp; je s&uacute;&#269;et at&oacute;mov&yacute;ch hmotnost&iacute; at&oacute;mov danej molekuly.&lt;\/div&gt;\" href=\"https:\/\/www.fipwarriors.eu\/en\/glossary\/molarna-hmotnost\/\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">Molekulov&aacute; hmotnos&#357;<\/a>:   329.31<\/li>\n\n\n\n<li> [(2<em>R<\/em>,3<em>S<\/em>,4<em>R<\/em>,5<em>R<\/em>)-3,4-dihydroxy-5-[4-(hydroxyamino)-2-oxopyrimidin-1-yl]oxolan-2-yl]methyl 2-methylpropanoate<\/li>\n\n\n\n<li>Synonymum:  MK-4482 <\/li>\n\n\n\n<li>EIDD-1931 prodrug<\/li>\n\n\n\n<li>Patent# <a class=\"\" href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/patent\/WO-2019173602-A1\">WO-2019173602-A1<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.chemsrc.com\/en\/cas\/2349386-89-4_1564121.html\" target=\"_blank\" rel=\"noreferrer noopener\">ChemSrc<\/a>, <a href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/145996610\" target=\"_blank\" rel=\"noreferrer noopener\">PubChem<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">EIDD-2801 sa sk&uacute;ma pre jeho aktivitu proti mnoh&yacute;m v&iacute;rusov&yacute;m infekci&aacute;m vr&aacute;tane chr&iacute;pky, MERS-CoV a SARS-CoV-2.<\/p>\n<\/div><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"346\" height=\"500\" src=\"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/08\/EIDD-2801_500crop.gif\" alt=\"\" class=\"wp-image-8122 size-full\"\/><\/figure><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Mechanizmus &uacute;&#269;inku<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">EIDD-2801 je or&aacute;lne biologicky dostupn&yacute; izopropylesterov&yacute; <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemBody&gt;&amp;lt;b&amp;gt;Prekurzor&amp;lt;\/b&amp;gt; je v&yacute;chodiskov&aacute; l&aacute;tka, &#269;astica, z ktorej vznik&aacute; chemickou premenou v&yacute;sledn&yacute; produkt.&lt;\/div&gt;\" href=\"https:\/\/www.fipwarriors.eu\/en\/glossary\/prekurzor\/\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">prekurzor<\/a> ribonukleozidov&eacute;ho anal&oacute;gu EIDD-1931 ( N4-hydroxycytid&iacute;n ). Hydrolyzuje sa <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemBody&gt;in vivo - lat. &amp;quot;V &#382;ivom&amp;quot;, v &#382;ivom organizme, &#318;udskom alebo zvieracom. M&ocirc;&#382;e sa t&yacute;ka&#357; ako pokuse aj skuto&#269;n&eacute;ho priebehu ur&#269;it&eacute;ho deja alebo choroby. Porov. in vitro lat. in v; Vivus &#382;iv&yacute;&lt;\/div&gt;\" href=\"https:\/\/www.fipwarriors.eu\/en\/glossary\/in-vivo\/\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">in vivo<\/a> a distribuuje sa do tkan&iacute;v, kde sa st&aacute;va akt&iacute;vnou formou 5&rsquo;-trifosf&aacute;tu. Akt&iacute;vne lie&#269;ivo sa za&#269;le&#328;uje do gen&oacute;mu <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemBody&gt;Ribonukleov&aacute; kyselina. Polymern&iacute; makromolekula, jej&iacute;&#382; z&aacute;kladn&iacute;mi stavebn&iacute;mi jednotkami jsou ribonukleotidy. Je sou&#269;&aacute;st&iacute; v&scaron;ech bun&#283;k a slou&#382;&iacute; k p&#345;enosu informac&iacute; z DNA d&aacute;le do bu&#328;ky. Existuje mnoho druh&#367; RNA s r&#367;zn&yacute;mi funkcemi. Mezi nejzn&aacute;mn&#283;j&scaron;&iacute; pat&#345;&iacute; mRNA (medi&aacute;torov&aacute;), tRNA (transferov&aacute;) a rRNA (ribozom&aacute;ln&iacute;).&lt;\/div&gt;\" href=\"https:\/\/www.fipwarriors.eu\/en\/glossary\/rna\/\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">RNA<\/a> v&iacute;rusov, &#269;o vedie k akumul&aacute;cii mut&aacute;ci&iacute; zn&aacute;mych ako v&iacute;rusov&aacute; chybov&aacute; katastrofa. Ned&aacute;vne &scaron;t&uacute;die uk&aacute;zali, &#382;e EIDD-2801 inhibuje replik&aacute;ciu &#318;udsk&yacute;ch a netopier&iacute;ch koronav&iacute;rusov, vr&aacute;tane SARS-CoV-2, u my&scaron;&iacute; a epiteli&aacute;lnych buniek &#318;udsk&yacute;ch d&yacute;chac&iacute;ch ciest. Uk&aacute;zalo sa, &#382;e aj vo&#269;i remdesiviru rezistentn&yacute; mutantn&yacute; my&scaron;&iacute; v&iacute;rus hepatit&iacute;dy m&aacute; zv&yacute;&scaron;en&uacute; citlivos&#357; na N4-hydroxycytid&iacute;n.  EIDD-2801 vykazuje aktivitu proti v&iacute;rusu chr&iacute;pky a koronav&iacute;rusom. EIDD-2801 m&aacute; potenci&aacute;l pre lie&#269;bu sez&oacute;nnej a pandemickej chr&iacute;pky. <\/p>\n\n\n\n<h2 class=\"wp-block-heading\">D&aacute;vkovanie a d&#314;&#382;ka lie&#269;by<\/h2>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<ul style=\"background-color:#99fdd5\" class=\"wp-block-list lm-round has-black-color has-text-color has-background\">\n<li>Vlhk&aacute;\/Such&aacute; <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemBody&gt;Infek&#269;n&aacute; peritonit&iacute;da ma&#269;iek (angl. Feline infectious peritonitis, zau&#382;&iacute;van&aacute; skratka FIP) je infek&#269;n&eacute; ochorenie ma&#269;iek sp&ocirc;sobuj&uacute;ce smr&#357;. N&aacute;zov je mierne zav&aacute;dzaj&uacute;ci, preto&#382;e nejde o z&aacute;pal pobru&scaron;nice (&#269;i&#382;e peritonea), ale o z&aacute;pal ciev (vaskulit&iacute;da). Klinick&eacute; pr&iacute;znaky FIP sa v&scaron;ak &#269;asto prejavuj&uacute; vo forme z&aacute;palu pobru&scaron;nice. V&iacute;rus FIP nap&aacute;da v&scaron;ak aj pohrudnicu &ndash; z toho d&ocirc;vodu je niekedy choroba ozna&#269;ovan&aacute; tie&#382; ako Infek&#269;n&aacute; ma&#269;acia polyserozit&iacute;da (Feline infectious polyserositis).&lt;\/div&gt;\" href=\"https:\/\/www.fipwarriors.eu\/en\/glossary\/fip\/\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">FIP<\/a>: cca 8-10 mg\/kg q12h<\/li>\n\n\n\n<li>Okul&aacute;rna FIP: 10-15 mg\/kg q12h<\/li>\n\n\n\n<li>Neurologick&aacute; FIP: 15-20 mg\/kg q12h<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<p class=\"lm-round has-luminous-vivid-amber-background-color has-background wp-block-paragraph\">Ako u&#382; bolo zmienen&eacute;, EIDD-2801 je prekurzorom EIDD-1931. Vz&#357;ah EIDD-2801 ku EIDD-1931 je teda ekvivalentom vz&#357;ahu Remdesiviru a GS-441524. Ke&#271;&#382;e molekulov&aacute; hmotnos&#357; EIDD-2801 je 329.31 g-mol a EIDD-1931 259.22&nbsp;g\/mol, d&aacute; sa predpoklada&#357;, ze vz&#357;ah d&aacute;vkovania EIDD-2801 a EIDD-1931 sa riadi pomerom 1.27 . In&yacute;mi slovami, pokia&#318; pou&#382;ijeme EIDD-1931 v d&aacute;vkovan&iacute; 10mg\/kg, mali by sme pre EIDD-2801 pou&#382;it cca 12.7mg\/kg. <br>Na tomto mieste treba poznamena&#357;, &#382;e EIDD-1931 nie je komer&#269;ne roz&scaron;&iacute;ren&yacute; a s najva&#269;&scaron;ou pravdepodobnos&#357;ou sa stretnete s EIDD-2801. Existenciu EIDD-1931 ale treba ma&#357; na pam&auml;ti pre pr&iacute;pad, &#382;e by ste sa k tomuto lieku dostali.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><span style=\"color: #cf2e2e;\" class=\"stk-highlight\">Farmakokinetika EIDD-2801 je in&aacute; ako u GS441524 a preto sa lieky pod&aacute;vaj&uacute; dvakr&aacute;t denne. Doporu&#269;ujem pre&#269;&iacute;ta&#357; ni&#382;&scaron;ie uveden&eacute; &#269;l&aacute;nky. <\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.fipwarriors.eu\/alternativna-liecba-maciek-s-fip-a-prirodzenou-alebo-ziskanou-rezistenciou-na-gs-441524\/\">Alternat&iacute;vna lie&#269;ba ma&#269;iek s FIP a prirodzenou alebo z&iacute;skanou rezistenciou vo&#269;i GS-441524<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.fipwarriors.eu\/dlha-historia-beta-d-n4-hydroxycytidinu-a-jeho-moderna-aplikacia-na-liecbu-covid-19-u-ludi-a-fip-u-maciek\/\">Dlh&aacute; hist&oacute;ria Beta-d-N4-hydroxycytid&iacute;nu a jeho modern&aacute; aplik&aacute;cia na lie&#269;bu Covid-19 u &#318;ud&iacute; a FIP u ma&#269;iek.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.fipwarriors.eu\/kalkulacka-eidd\/\" target=\"_blank\" rel=\"noreferrer noopener\">Kalkula&#269;ka d&aacute;vky pre Molnupiravir<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><span style=\"color: #cf2e2e;\" class=\"stk-highlight\">Treba si uvedomi&#357;, &#382;e k&yacute;m lie&#269;ba Covid-19 u &#318;ud&iacute; trv&aacute; 5 dn&iacute;, lie&#269;ba FIP trv&aacute; omnoho dlh&scaron;ie a EIDD-2801 (Molnupiravir) m&ocirc;&#382;e ma&#357; ved&#318;aj&scaron;ie  mutag&eacute;nne &uacute;&#269;inky, ktor&eacute; e&scaron;te nie s&uacute; do d&ocirc;sledkov presk&uacute;man&eacute; a m&ocirc;&#382;u vies&#357; napr&iacute;klad k vzniku rakoviny. Z toho d&ocirc;vodu sa doporu&#269;uje lie&#269;i&#357; FIP pomocou osved&#269;en&eacute;ho GS441521 a po Molnupiravire siahnu&#357; a&#382; v pr&iacute;pade rezistencie na GS441524.<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Dostupnos&#357; Molnupiraviru v &#268;R\/SR<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright size-medium\"><a href=\"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/12\/lagevrio.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"169\" src=\"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/12\/lagevrio-300x169.jpg\" alt=\"\" class=\"wp-image-9476\" srcset=\"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/12\/lagevrio-300x169.jpg 300w, https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/12\/lagevrio-1024x576.jpg 1024w, https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/12\/lagevrio-768x432.jpg 768w, https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/12\/lagevrio-18x10.jpg 18w, https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/12\/lagevrio-350x197.jpg 350w, https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/12\/lagevrio-64x36.jpg 64w, https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/12\/lagevrio.jpg 1029w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\"\/><\/a><figcaption class=\"wp-element-caption\">Lagevrio<\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">Na rozdiel od GC441524 sa Molnupiravir d&aacute; okrem &#269;ierneho trhu ziska&#357; aj leg&aacute;lnym sp&ocirc;sobom na lie&#269;bu Covid-19. Liek je samozrejme na predpis.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft size-medium\"><a href=\"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/05\/20220421_reuters_molnupiravir_0.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/05\/20220421_reuters_molnupiravir_0-300x300.jpg\" alt=\"\" class=\"wp-image-10465\" srcset=\"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/05\/20220421_reuters_molnupiravir_0-300x300.jpg 300w, https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/05\/20220421_reuters_molnupiravir_0-150x150.jpg 150w, https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/05\/20220421_reuters_molnupiravir_0-12x12.jpg 12w, https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/05\/20220421_reuters_molnupiravir_0-100x100.jpg 100w, https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/05\/20220421_reuters_molnupiravir_0-250x250.jpg 250w, https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/05\/20220421_reuters_molnupiravir_0-350x350.jpg 350w, https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/05\/20220421_reuters_molnupiravir_0-64x64.jpg 64w, https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/05\/20220421_reuters_molnupiravir_0.jpg 538w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\"\/><\/a><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">7.12.2021 rozhodlo Ministerstvo zdravotn&iacute;ctva &#268;R o <a href=\"https:\/\/www.mzcr.cz\/wp-content\/uploads\/2021\/12\/Rozhodnuti-o-docasnem-povoleni-distribuce-vydeje-a-pouzivani-leciveho-pripravku-LAGEVRIO.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">do&#269;asnom povolen&iacute;<\/a> Molnupiraviru s komer&#269;n&yacute;m n&aacute;zvom Lagevrio. Jedno balenie obsahuje 40 toboliek s obsahom Molnupiraviru 200mg. Nev&yacute;hodou t&yacute;chto toboliek je pr&iacute;li&scaron; vysok&yacute; obsah &uacute;&#269;innej l&aacute;tky a ve&#318;mi komplikovan&eacute; delenie pre pou&#382;itie u ma&#269;iek. Ka&#382;dop&aacute;dne 1 balenie by malo sta&#269;i&#357; na cel&uacute; lie&#269;bu oby&#269;ajnej vlhkej\/suchej FIP pre ma&#269;ku o hmotnosti do cca 8 kg. Okul&aacute;rna a neurologick&aacute; FIP podobne ako u GS441524 vy&#382;aduj&uacute; vy&scaron;&scaron;ie d&aacute;vkovanie. Vzh&#318;adom na to, &#382;e Lagevrio obsahuje Molnupiravir v pr&aacute;&scaron;kovej forme, nie je mo&#382;n&eacute; delenie tobolky v dom&aacute;cich podmienkach a je nutn&eacute; jej &bdquo;prekapslovanie&ldquo; do men&scaron;&iacute;ch toboliek, napr. 20mg, ide&aacute;lne v lek&aacute;rni. Tak&#382;e zo 40 kapsl&iacute; Lavegrio 200mg by ste mali z&iacute;skat 400 kapsl&iacute; 20mg. Je to spoplatnen&aacute; slu&#382;ba. Bez toho je prakticky nemo&#382;n&eacute; dosiahnu&#357; pou&#382;ite&#318;n&eacute; d&aacute;vkovanie pre ma&#269;ku.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Pod&#318;a posledn&yacute;ch inform&aacute;ci&iacute; (05.2022) je skuto&#269;ne mo&#382;n&eacute; Lagevrio v lek&aacute;rni objedna&#357; s platn&yacute;m (i veterin&aacute;rnym) receptom za cca 18-22 tis&iacute;c K&#269;.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.sukl.cz\/file\/97529_1_1\/\" target=\"_blank\" rel=\"noreferrer noopener\">P&#345;&iacute;balov&aacute; informace o p&#345;&iacute;pravku Lagevrio<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.sukl.cz\/file\/97528_1_1\/\" target=\"_blank\" rel=\"noreferrer noopener\">Souhrn informac&iacute; o p&#345;&iacute;pravku Lagevrio<\/a><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">&#270;al&scaron;&iacute; v&yacute;robcovia Molnupiraviru<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Na inform&aacute;cie o &uacute;&#269;innosti Molnupiraviru pri lie&#269;be FIP samozrejme okam&#382;ite reagovali aj &#269;&iacute;nski v&yacute;robcovia liekov, ktor&iacute; produkovali GC-376, alebo GS-441524. A tak sa na trhu objavili tablety zna&#269;ky Hero  (Hero Plus), Lucky, Kitty Care atd atd.<\/p>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-d7eb9b4\" id=\"dalsie-zdroje-informacii-o-molnupiravire-a-jeho-vyuziti-pri-liecbe-fip\" data-block-id=\"d7eb9b4\"><style>.stk-d7eb9b4 {margin-bottom:13px !important;}<\/style><h2 class=\"stk-block-heading__text\">&#270;al&scaron;ie zdroje inform&aacute;ci&iacute; o molnupiravire a jeho vyu&#382;it&iacute; pri lie&#269;be FIP<\/h2><\/div>\n\n\n<div id=\"caf-post-layout-container\" class=\"caf-post-layout-container \r\n     filter-layout1 post-layout1 \r\n     data-target-div1\" data-post-type=\"post\" data-tax=\"post_tag\" data-terms=\"post_tag___271\" data-per-page=\"12\" data-selected-terms=\"category___189,category___191,category___193,category___187,category___192,category___188,category___190,category___230\" data-filter-id=\"12058\" data-post-layout=\"post-layout1\" data-filter-layout=\"filter-layout1\" data-target-div=\"data-target-div1\" data-relation=\"IN\" data-default-term=\"post_tag___271\" data-scroll=\"desktop\" data-scroll-desk=\"-100\" data-scroll-mob=\"-100\" current-post-id=\"8119\" data-order-by=\"date\" data-order-type=\"desc\" active-filters=\"on\" active-filters-style=\"without_tax\"><div class=\"caf-active-filters\"><ul><\/ul><\/div><div id=\"manage-ajax-response\" class=\"caf-row\"><div class=\"status\"><i class=\"fa fa-spinner\" aria-hidden=\"true\"><\/i><\/div><div class=\"content\"><\/div><\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mechanism of action EIDD-2801 is an orally bioavailable isopropyl ester precursor of the ribonucleoside analogue EIDD-1931 (N4-hydroxycytidine). It is hydrolyzed in vivo and distributed to tissues, where it becomes the active form of 5&#039;-triphosphate. The active drug is incorporated into the genome of RNA viruses, leading to an accumulation of mutations known as viral error catastrophe. Recent studies have shown that EIDD-2801 inhibits the replication of... <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.fipwarriors.eu\/en\/eidd-2801-molnupiravir\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &quot;EIDD-2801 (Molnupiravir)&quot;<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":8144,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_uag_custom_page_level_css":"","footnotes":""},"categories":[],"tags":[],"class_list":["post-8119","page","type-page","status-publish","has-post-thumbnail","hentry"],"featured_image_urls_v2":{"full":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/08\/molnupiravir-FHD-crop.jpg",1920,756,false],"thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/08\/molnupiravir-FHD-crop-150x150.jpg",150,150,true],"medium":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/08\/molnupiravir-FHD-crop-300x118.jpg",300,118,true],"medium_large":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/08\/molnupiravir-FHD-crop-768x302.jpg",525,206,true],"large":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/08\/molnupiravir-FHD-crop-1024x403.jpg",525,207,true],"1536x1536":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/08\/molnupiravir-FHD-crop-1536x605.jpg",1536,605,true],"2048x2048":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/08\/molnupiravir-FHD-crop.jpg",1920,756,false],"trp-custom-language-flag":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/08\/molnupiravir-FHD-crop-18x7.jpg",18,7,true],"twentyseventeen-featured-image":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/08\/molnupiravir-FHD-crop.jpg",1920,756,false],"twentyseventeen-thumbnail-avatar":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/08\/molnupiravir-FHD-crop-100x100.jpg",100,100,true],"woocommerce_thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/08\/molnupiravir-FHD-crop-250x250.jpg",250,250,true],"woocommerce_single":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/08\/molnupiravir-FHD-crop-350x138.jpg",350,138,true],"woocommerce_gallery_thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/08\/molnupiravir-FHD-crop-100x100.jpg",100,100,true]},"post_excerpt_stackable_v2":"<p>Molekulov&yacute; vzorec: C13H19N3O7 CAS# 2349386-89-4 Molekulov&aacute; hmotnos&#357;: 329.31 [(2R,3S,4R,5R)-3,4-dihydroxy-5-[4-(hydroxyamino)-2-oxopyrimidin-1-yl]oxolan-2-yl]methyl 2-methylpropanoate Synonymum: MK-4482 EIDD-1931 prodrug Patent# WO-2019173602-A1 ChemSrc, PubChem EIDD-2801 sa sk&uacute;ma pre jeho aktivitu proti mnoh&yacute;m v&iacute;rusov&yacute;m infekci&aacute;m vr&aacute;tane chr&iacute;pky, MERS-CoV a SARS-CoV-2. Mechanizmus &uacute;&#269;inku EIDD-2801 je or&aacute;lne biologicky dostupn&yacute; izopropylesterov&yacute; <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemBody&gt;&amp;lt;b&amp;gt;Prekurzor&amp;lt;\/b&amp;gt; je v&yacute;chodiskov&aacute; l&aacute;tka, &#269;astica, z ktorej vznik&aacute; chemickou premenou v&yacute;sledn&yacute; produkt.&lt;\/div&gt;\" href=\"https:\/\/www.fipwarriors.eu\/en\/glossary\/prekurzor\/\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">prekurzor<\/a> ribonukleozidov&eacute;ho anal&oacute;gu EIDD-1931 ( N4-hydroxycytid&iacute;n ). Hydrolyzuje sa <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemBody&gt;in vivo - lat. &amp;quot;V &#382;ivom&amp;quot;, v &#382;ivom organizme, &#318;udskom alebo zvieracom. M&ocirc;&#382;e sa t&yacute;ka&#357; ako pokuse aj skuto&#269;n&eacute;ho priebehu ur&#269;it&eacute;ho deja alebo choroby. Porov. in vitro lat. in v; Vivus &#382;iv&yacute;&lt;\/div&gt;\" href=\"https:\/\/www.fipwarriors.eu\/en\/glossary\/in-vivo\/\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">in vivo<\/a> a distribuuje sa do tkan&iacute;v, kde sa st&aacute;va akt&iacute;vnou formou 5&rsquo;-trifosf&aacute;tu. Akt&iacute;vne lie&#269;ivo sa za&#269;le&#328;uje do gen&oacute;mu <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemBody&gt;Ribonukleov&aacute; kyselina. Polymern&iacute; makromolekula, jej&iacute;&#382; z&aacute;kladn&iacute;mi stavebn&iacute;mi jednotkami jsou ribonukleotidy. Je sou&#269;&aacute;st&iacute; v&scaron;ech bun&#283;k a slou&#382;&iacute; k p&#345;enosu informac&iacute; z DNA d&aacute;le do bu&#328;ky. Existuje mnoho druh&#367; RNA s r&#367;zn&yacute;mi funkcemi. Mezi nejzn&aacute;mn&#283;j&scaron;&iacute; pat&#345;&iacute; mRNA (medi&aacute;torov&aacute;), tRNA (transferov&aacute;) a rRNA (ribozom&aacute;ln&iacute;).&lt;\/div&gt;\" href=\"https:\/\/www.fipwarriors.eu\/en\/glossary\/rna\/\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">RNA<\/a> v&iacute;rusov, &#269;o vedie k akumul&aacute;cii mut&aacute;ci&iacute; zn&aacute;mych ako v&iacute;rusov&aacute; chybov&aacute; katastrofa. Ned&aacute;vne &scaron;t&uacute;die uk&aacute;zali, &#382;e EIDD-2801 inhibuje replik&aacute;ciu &#318;udsk&yacute;ch a netopier&iacute;ch koronav&iacute;rusov, vr&aacute;tane SARS-CoV-2, u my&scaron;&iacute; a epiteli&aacute;lnych buniek &#318;udsk&yacute;ch&hellip;<\/p>\n","category_list_v2":"Uncategorised","author_info_v2":{"name":"LM","url":"https:\/\/www.fipwarriors.eu\/en\/author\/starman\/"},"comments_num_v2":"0 comments","featured_image_src":"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/08\/molnupiravir-FHD-crop.jpg","yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>EIDD-2801 (Molnupiravir) - FIP Warriors CZ\/SK \u00ae<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.fipwarriors.eu\/en\/eidd-2801-molnupiravir\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"EIDD-2801 (Molnupiravir) - FIP Warriors CZ\/SK \u00ae\" \/>\n<meta property=\"og:description\" content=\"Mechanizmus &uacute;&#269;inku EIDD-2801 je or&aacute;lne biologicky dostupn&yacute; izopropylesterov&yacute; prekurzor ribonukleozidov&eacute;ho anal&oacute;gu EIDD-1931 ( N4-hydroxycytid&iacute;n ). Hydrolyzuje sa in vivo a distribuuje sa do tkan&iacute;v, kde sa st&aacute;va akt&iacute;vnou formou 5&rsquo;-trifosf&aacute;tu. Akt&iacute;vne lie&#269;ivo sa za&#269;le&#328;uje do gen&oacute;mu RNA v&iacute;rusov, &#269;o vedie k akumul&aacute;cii mut&aacute;ci&iacute; zn&aacute;mych ako v&iacute;rusov&aacute; chybov&aacute; katastrofa. Ned&aacute;vne &scaron;t&uacute;die uk&aacute;zali, &#382;e EIDD-2801 inhibuje replik&aacute;ciu &hellip; Continue reading &quot;EIDD-2801 (Molnupiravir)&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.fipwarriors.eu\/en\/eidd-2801-molnupiravir\/\" \/>\n<meta property=\"og:site_name\" content=\"FIP Warriors CZ\/SK \u00ae\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/groups\/fipczsk\" \/>\n<meta property=\"article:modified_time\" content=\"2025-07-24T13:49:30+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/08\/molnupiravir-FHD-crop.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"756\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.fipwarriors.eu\\\/eidd-2801-molnupiravir\\\/\",\"url\":\"https:\\\/\\\/www.fipwarriors.eu\\\/eidd-2801-molnupiravir\\\/\",\"name\":\"EIDD-2801 (Molnupiravir) - FIP Warriors CZ\\\/SK \u00ae\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.fipwarriors.eu\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.fipwarriors.eu\\\/eidd-2801-molnupiravir\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.fipwarriors.eu\\\/eidd-2801-molnupiravir\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.fipwarriors.eu\\\/wp-content\\\/uploads\\\/2021\\\/08\\\/molnupiravir-FHD-crop.jpg\",\"datePublished\":\"2021-08-01T21:42:25+00:00\",\"dateModified\":\"2025-07-24T13:49:30+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.fipwarriors.eu\\\/eidd-2801-molnupiravir\\\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.fipwarriors.eu\\\/eidd-2801-molnupiravir\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/www.fipwarriors.eu\\\/eidd-2801-molnupiravir\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.fipwarriors.eu\\\/wp-content\\\/uploads\\\/2021\\\/08\\\/molnupiravir-FHD-crop.jpg\",\"contentUrl\":\"https:\\\/\\\/www.fipwarriors.eu\\\/wp-content\\\/uploads\\\/2021\\\/08\\\/molnupiravir-FHD-crop.jpg\",\"width\":1920,\"height\":756},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.fipwarriors.eu\\\/eidd-2801-molnupiravir\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Domovsk\u00e1 str\u00e1nka\",\"item\":\"https:\\\/\\\/www.fipwarriors.eu\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"EIDD-2801 (Molnupiravir)\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.fipwarriors.eu\\\/#website\",\"url\":\"https:\\\/\\\/www.fipwarriors.eu\\\/\",\"name\":\"FIP Warriors CZ\\\/SK \u00ae\",\"description\":\"Pre v\u0161etk\u00fdch FIP bojovn\u00edkov\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.fipwarriors.eu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.fipwarriors.eu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.fipwarriors.eu\\\/#organization\",\"name\":\"FIP Warriors CZ\\\/SK \u00ae\",\"url\":\"https:\\\/\\\/www.fipwarriors.eu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/www.fipwarriors.eu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.fipwarriors.eu\\\/wp-content\\\/uploads\\\/2021\\\/12\\\/cropped-fip-warriors-logo.png\",\"contentUrl\":\"https:\\\/\\\/www.fipwarriors.eu\\\/wp-content\\\/uploads\\\/2021\\\/12\\\/cropped-fip-warriors-logo.png\",\"width\":315,\"height\":315,\"caption\":\"FIP Warriors CZ\\\/SK \u00ae\"},\"image\":{\"@id\":\"https:\\\/\\\/www.fipwarriors.eu\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/groups\\\/fipczsk\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"EIDD-2801 (Molnupiravir) - FIP Warriors CZ\/SK \u00ae","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.fipwarriors.eu\/en\/eidd-2801-molnupiravir\/","og_locale":"en_GB","og_type":"article","og_title":"EIDD-2801 (Molnupiravir) - FIP Warriors CZ\/SK \u00ae","og_description":"Mechanizmus &uacute;&#269;inku EIDD-2801 je or&aacute;lne biologicky dostupn&yacute; 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