{"id":10670,"date":"2021-09-03T22:00:00","date_gmt":"2021-09-03T20:00:00","guid":{"rendered":"https:\/\/www.fipwarriors.eu\/?p=10670"},"modified":"2023-03-29T09:49:25","modified_gmt":"2023-03-29T07:49:25","slug":"kombinovana-terapia-fluoxetinom-a-nukleozidovym-analogom-gs-441524-vykazuje-synergicke-antivirusove-ucinky-proti-roznym-variantom-sars-cov-2-in-vitro","status":"publish","type":"post","link":"https:\/\/www.fipwarriors.eu\/en\/kombinovana-terapia-fluoxetinom-a-nukleozidovym-analogom-gs-441524-vykazuje-synergicke-antivirusove-ucinky-proti-roznym-variantom-sars-cov-2-in-vitro\/","title":{"rendered":"Combination therapy with fluoxetine and the nucleoside analogue GS-441524 shows synergistic antiviral effects against various SARS-CoV-2 variants in vitro"},"content":{"rendered":"

Kompletný pôvodný článok: Combination Therapy with Fluoxetine and the Nucleoside Analog GS-441524 Exerts Synergistic Antiviral Effects against Different SARS-CoV-2 Variants In Vitro81\/<\/a><\/p>\n\n\n\n

Autori: Linda Brunotte, Shuyu Zheng, Angeles Mecate-Zambrano, Jing Tang, Stephan Ludwig, Ursula Rescher, and Sebastian Schloer<\/p>\n\n\n\n

Abstrakt<\/h2>\n\n\n\n

Prebiehajúca pandémia SARS-CoV-2 si vyžaduje účinné a bezpečné stratégie antivírusovej liečby. Repurposing liekov predstavuje rýchly a lacný prístup k vývoju nových možností liečby. Zistilo sa, že priamy antivírusový agens remdesivir vykazuje antivírusovú aktivitu proti SARS-CoV-2. Zatiaľ čo remdesivir má len veľmi krátky polčas rozpadu a bioaktiváciu, ktorá závisí od enzýmov aktivujúcich proliečivo, jeho plazmatický metabolit GS-441524 sa môže aktivovať prostredníctvom rôznych kináz vrátane adenozínkinázy (ADK), ktorá je stredne exprimovaná vo všetkých tkanivách. Farmakokinetika GS-441524 svedčí o tom, že ide o vhodné antivírusové liečivo, ktoré sa môže podávať pacientom s COVID-19. V tejto práci sme analyzovali antivírusové vlastnosti kombinovanej liečby metabolitom remdesiviru GS-441524 a antidepresívom fluoxetínom v polarizovanom modeli bunkovej kultúry Calu-3 proti SARS-CoV-2. Kombinovaná liečba s GS-441524 a fluoxetínom bola dobre tolerovaná a vykazovala synergické antivírusové účinky proti trom cirkulujúcim variantom SARS-CoV-2 in vitro<\/a> v bežne používaných referenčných modeloch pre liekové interakcie. Kombinovaná liečba liekom GS-441524 zameraným na vírus a liekom fluoxetínom zameraným na hostiteľa by teda mohla ponúknuť vhodnú terapeutickú možnosť liečby infekcií SARS-CoV-2. <\/p>\n\n\n\n

Poznámka prekladateľa: Fluoxetine sa vyrába pod rôznymi obchodnými názvami, z ktorých asi najznámejší je Prozac.<\/p>\n\n\n\n

… zvyšok si môžete prečítať v kompletnom článku v angličtine<\/a>. <\/p>\n","protected":false},"excerpt":{"rendered":"

Full original article: Combination Therapy with Fluoxetine and the Nucleoside Analog GS-441524 Exerts Synergistic Antiviral Effects against Different SARS-CoV-2 Variants In Vitro81\/ Authors: Linda Brunotte, Shuyu Zheng, Angeles Mecate-Zambrano, Jing Tang, Stephan Ludwig, Ursula Rescher, and Sebastian Schloer Abstract The ongoing SARS-CoV-2 pandemic requires effective and safe antiviral treatment strategies. The repurposing of medicines represents a quick and... <\/p>\n

Continue reading "Combination therapy with fluoxetine and the nucleoside analogue GS-441524 shows synergistic antiviral effects against different variants of SARS-CoV-2 in vitro"<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":10673,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","footnotes":""},"categories":[189,187,1],"tags":[],"class_list":["post-10670","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-abstrakt","category-odborne","category-genart"],"featured_image_urls_v2":{"full":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/06\/fluoxetine-fhd.jpg",1920,1080,false],"thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/06\/fluoxetine-fhd-150x150.jpg",150,150,true],"medium":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/06\/fluoxetine-fhd-300x169.jpg",300,169,true],"medium_large":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/06\/fluoxetine-fhd-768x432.jpg",525,295,true],"large":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/06\/fluoxetine-fhd-1024x576.jpg",525,295,true],"1536x1536":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/06\/fluoxetine-fhd-1536x864.jpg",1536,864,true],"2048x2048":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/06\/fluoxetine-fhd.jpg",1920,1080,false],"trp-custom-language-flag":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/06\/fluoxetine-fhd-18x10.jpg",18,10,true],"twentyseventeen-featured-image":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/06\/fluoxetine-fhd.jpg",1920,1080,false],"twentyseventeen-thumbnail-avatar":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/06\/fluoxetine-fhd-100x100.jpg",100,100,true],"woocommerce_thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/06\/fluoxetine-fhd-250x250.jpg",250,250,true],"woocommerce_single":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/06\/fluoxetine-fhd-350x197.jpg",350,197,true],"woocommerce_gallery_thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/06\/fluoxetine-fhd-100x100.jpg",100,100,true]},"post_excerpt_stackable_v2":"

Kompletný pôvodný článok: Combination Therapy with Fluoxetine and the Nucleoside Analog GS-441524 Exerts Synergistic Antiviral Effects against Different SARS-CoV-2 Variants In Vitro81\/ Autori: Linda Brunotte, Shuyu Zheng, Angeles Mecate-Zambrano, Jing Tang, Stephan Ludwig, Ursula Rescher, and Sebastian Schloer Abstrakt Prebiehajúca pandémia SARS-CoV-2 si vyžaduje účinné a bezpečné stratégie antivírusovej liečby. Repurposing liekov predstavuje rýchly a lacný prístup k vývoju nových možností liečby. Zistilo sa, že priamy antivírusový agens remdesivir vykazuje antivírusovú aktivitu proti SARS-CoV-2. Zatiaľ čo remdesivir má len veľmi krátky polčas rozpadu a bioaktiváciu, ktorá závisí od enzýmov aktivujúcich proliečivo, jeho plazmatický metabolit GS-441524 sa môže aktivovať prostredníctvom rôznych…<\/p>\n","category_list_v2":"Abstrakty<\/a>, Odborn\u00e9<\/a>, V\u0161eobecn\u00e9 \u010dl\u00e1nky<\/a>","author_info_v2":{"name":"LM","url":"https:\/\/www.fipwarriors.eu\/en\/author\/starman\/"},"comments_num_v2":"0 comments","featured_image_src":"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/06\/fluoxetine-fhd.jpg","author_info":{"display_name":"L. M.","author_link":"https:\/\/www.fipwarriors.eu\/en\/author\/starman\/"},"yoast_head":"\nKombinovan\u00e1 terapia fluoxet\u00ednom a nukleozidov\u00fdm anal\u00f3gom GS-441524 vykazuje synergick\u00e9 antiv\u00edrusov\u00e9 \u00fa\u010dinky proti r\u00f4znym variantom SARS-CoV-2 in vitro - FIP Warriors CZ\/SK \u00ae<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.fipwarriors.eu\/en\/kombinovana-terapia-fluoxetinom-a-nukleozidovym-analogom-gs-441524-vykazuje-synergicke-antivirusove-ucinky-proti-roznym-variantom-sars-cov-2-in-vitro\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Kombinovan\u00e1 terapia fluoxet\u00ednom a nukleozidov\u00fdm anal\u00f3gom GS-441524 vykazuje synergick\u00e9 antiv\u00edrusov\u00e9 \u00fa\u010dinky proti r\u00f4znym variantom SARS-CoV-2 in vitro - FIP Warriors CZ\/SK \u00ae\" \/>\n<meta property=\"og:description\" content=\"Kompletný pôvodný článok: Combination Therapy with Fluoxetine and the Nucleoside Analog GS-441524 Exerts Synergistic Antiviral Effects against Different SARS-CoV-2 Variants In Vitro81\/ Autori: Linda Brunotte, Shuyu Zheng, Angeles Mecate-Zambrano, Jing Tang, Stephan Ludwig, Ursula Rescher, and Sebastian Schloer Abstrakt Prebiehajúca pandémia SARS-CoV-2 si vyžaduje účinné a bezpečné stratégie antivírusovej liečby. Repurposing liekov predstavuje rýchly a … Continue reading "Kombinovaná terapia fluoxetínom a nukleozidovým analógom GS-441524 vykazuje synergické antivírusové účinky proti rôznym variantom SARS-CoV-2 in vitro"\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.fipwarriors.eu\/en\/kombinovana-terapia-fluoxetinom-a-nukleozidovym-analogom-gs-441524-vykazuje-synergicke-antivirusove-ucinky-proti-roznym-variantom-sars-cov-2-in-vitro\/\" \/>\n<meta property=\"og:site_name\" content=\"FIP Warriors CZ\/SK \u00ae\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/groups\/fipczsk\" \/>\n<meta property=\"article:published_time\" content=\"2021-09-03T20:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-29T07:49:25+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/06\/fluoxetine-fhd.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"L. 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M.","author_link":"https:\/\/www.fipwarriors.eu\/en\/author\/starman\/"},"uagb_comment_info":0,"uagb_excerpt":"Kompletný pôvodný článok: Combination Therapy with Fluoxetine and the Nucleoside Analog GS-441524 Exerts Synergistic Antiviral Effects against Different SARS-CoV-2 Variants In Vitro81\/ Autori: Linda Brunotte, Shuyu Zheng, Angeles Mecate-Zambrano, Jing Tang, Stephan Ludwig, Ursula Rescher, and Sebastian Schloer Abstrakt Prebiehajúca pandémia SARS-CoV-2 si vyžaduje účinné a bezpečné stratégie antivírusovej liečby. Repurposing liekov predstavuje rýchly a…","_links":{"self":[{"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/posts\/10670","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/comments?post=10670"}],"version-history":[{"count":1,"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/posts\/10670\/revisions"}],"predecessor-version":[{"id":11698,"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/posts\/10670\/revisions\/11698"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/media\/10673"}],"wp:attachment":[{"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/media?parent=10670"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/categories?post=10670"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/tags?post=10670"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}