{"id":10687,"date":"2022-06-18T14:08:09","date_gmt":"2022-06-18T12:08:09","guid":{"rendered":"https:\/\/www.fipwarriors.eu\/?p=10687"},"modified":"2023-09-07T16:36:09","modified_gmt":"2023-09-07T14:36:09","slug":"ec22-007-eidd-2801-molnupiravir-stanovenie-peroralneho-davkovania-a-dokaz-o-jeho-ucinnosti-u-maciek-s-fip","status":"publish","type":"post","link":"https:\/\/www.fipwarriors.eu\/en\/ec22-007-eidd-2801-molnupiravir-stanovenie-peroralneho-davkovania-a-dokaz-o-jeho-ucinnosti-u-maciek-s-fip\/","title":{"rendered":"EC22-007: EIDD-2801 (Molnupiravir): determination of oral dosage and confirmation of its efficacy in cats with FIP"},"content":{"rendered":"

Pôvodný článok: EC22-007: EIDD-2801 (Molnupiravir): establishing an oral dose and evidence for efficacy in cats with <\/a>FIP<\/a><\/p>\n\n\n\n

Mačacia infekčná peritonitída (FIP) je vysoko fatálne vírusové ochorenie mačiek s celosvetovým výskytom. Nedávno sa ukázalo, že pri liečbe mačiek s FIP je sľubných niekoľko antivírusových látok. Napriek týmto zisteniam v súčasnosti neexistuje žiadna legálna liečba FIP schválená Úradom pre kontrolu potravín a liečiv (FDA), takže mnohí majitelia sa obracajú na nelicencované antivirotiká zakúpené online. V dôsledku prebiehajúcej pandémie COVID-19 bolo nedávno schválených niekoľko antivirotík na perorálne použitie u ľudských pacientov. Jedným z týchto antivirotík je nukleozidový analóg EIDD-2801 (molnupiravir). EIDD-2801 spôsobuje hypermutáciu vyvíjajúcej sa vírusovej RNA<\/a>, čím účinne ukončuje vírusovú replikáciu mnohých rozličných RNA vírusov. Táto antivírusová látka bola vyvinutá na perorálne použitie u ľudských pacientov v domácom prostredí. Využitie EIDD-2801 v humánnej medicíne môže uľahčiť veterinárne použitie. Perorálne užívaná antivírusová zlúčenina by bola výhodná pre liečbu mačiek s FIP aplikovanú klientom. Určíme účinné perorálne dávkovanie EIDD-2801 a posúdime účinnosť tejto zlúčeniny pri domácej liečbe mačiek vo vlastníctve klienta s prirodzene sa vyskytujúcou efuzívnou FIP.<\/p>\n\n\n\n

(Bria Fund)<\/p>\n\n\n\n

Grant ID: <\/strong>EC22-007
Status: <\/strong>Aktívny
Rok: <\/strong>2022
Výška grantu: $<\/strong>33,550
Investigator: <\/strong>Brian Murphy, DVM, PhD, Dip ACP; Krystle Reagan, DVM, PhD, Dip ACVIM (SAIM); University of California, Davis<\/p>\n","protected":false},"excerpt":{"rendered":"

Grant to determine the correct oral dosage of Molnupiravir for the treatment of effusive FIP.<\/p>","protected":false},"author":1,"featured_media":10690,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","footnotes":""},"categories":[230],"tags":[271],"class_list":["post-10687","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-projekty","tag-eidd"],"featured_image_urls_v2":{"full":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/06\/molnupiravir-capsules-FHD.jpg",1920,1080,false],"thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/06\/molnupiravir-capsules-FHD-150x150.jpg",150,150,true],"medium":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/06\/molnupiravir-capsules-FHD-300x169.jpg",300,169,true],"medium_large":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/06\/molnupiravir-capsules-FHD-768x432.jpg",525,295,true],"large":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/06\/molnupiravir-capsules-FHD-1024x576.jpg",525,295,true],"1536x1536":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/06\/molnupiravir-capsules-FHD-1536x864.jpg",1536,864,true],"2048x2048":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/06\/molnupiravir-capsules-FHD.jpg",1920,1080,false],"trp-custom-language-flag":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/06\/molnupiravir-capsules-FHD-18x10.jpg",18,10,true],"twentyseventeen-featured-image":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/06\/molnupiravir-capsules-FHD.jpg",1920,1080,false],"twentyseventeen-thumbnail-avatar":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/06\/molnupiravir-capsules-FHD-100x100.jpg",100,100,true],"woocommerce_thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/06\/molnupiravir-capsules-FHD-250x250.jpg",250,250,true],"woocommerce_single":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/06\/molnupiravir-capsules-FHD-350x197.jpg",350,197,true],"woocommerce_gallery_thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/06\/molnupiravir-capsules-FHD-100x100.jpg",100,100,true]},"post_excerpt_stackable_v2":"

Grant pre stanovenie správneho perorálneho dávkovania Molnupiraviru pre liečbu efuzívnej FIP<\/a>.<\/p>\n","category_list_v2":"Projekty<\/a>","author_info_v2":{"name":"LM","url":"https:\/\/www.fipwarriors.eu\/en\/author\/starman\/"},"comments_num_v2":"0 comments","featured_image_src":"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/06\/molnupiravir-capsules-FHD.jpg","author_info":{"display_name":"L. M.","author_link":"https:\/\/www.fipwarriors.eu\/en\/author\/starman\/"},"yoast_head":"\nEC22-007: EIDD-2801 (Molnupiravir): stanovenie peror\u00e1lneho d\u00e1vkovania a potvrdenie jeho \u00fa\u010dinnosti u ma\u010diek s FIP - FIP Warriors CZ\/SK \u00ae<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.fipwarriors.eu\/en\/ec22-007-eidd-2801-molnupiravir-stanovenie-peroralneho-davkovania-a-dokaz-o-jeho-ucinnosti-u-maciek-s-fip\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"EC22-007: EIDD-2801 (Molnupiravir): stanovenie peror\u00e1lneho d\u00e1vkovania a potvrdenie jeho \u00fa\u010dinnosti u ma\u010diek s FIP - FIP Warriors CZ\/SK \u00ae\" \/>\n<meta property=\"og:description\" content=\"Grant pre stanovenie správneho perorálneho dávkovania Molnupiraviru pre liečbu efuzívnej FIP.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.fipwarriors.eu\/en\/ec22-007-eidd-2801-molnupiravir-stanovenie-peroralneho-davkovania-a-dokaz-o-jeho-ucinnosti-u-maciek-s-fip\/\" \/>\n<meta property=\"og:site_name\" content=\"FIP Warriors CZ\/SK \u00ae\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/groups\/fipczsk\" \/>\n<meta property=\"article:published_time\" content=\"2022-06-18T12:08:09+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-09-07T14:36:09+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/06\/molnupiravir-capsules-FHD.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"L. M.\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"L. M.\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.fipwarriors.eu\\\/ec22-007-eidd-2801-molnupiravir-stanovenie-peroralneho-davkovania-a-dokaz-o-jeho-ucinnosti-u-maciek-s-fip\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.fipwarriors.eu\\\/ec22-007-eidd-2801-molnupiravir-stanovenie-peroralneho-davkovania-a-dokaz-o-jeho-ucinnosti-u-maciek-s-fip\\\/\"},\"author\":{\"name\":\"L. 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