{"id":11377,"date":"2022-11-28T11:18:05","date_gmt":"2022-11-28T10:18:05","guid":{"rendered":"https:\/\/www.fipwarriors.eu\/?p=11377"},"modified":"2023-03-29T09:48:52","modified_gmt":"2023-03-29T07:48:52","slug":"stav-liecby-a-prevencie-fip-v-roku-2022","status":"publish","type":"post","link":"https:\/\/www.fipwarriors.eu\/en\/stav-liecby-a-prevencie-fip-v-roku-2022\/","title":{"rendered":"Status of FIP treatment and prevention in 2022"},"content":{"rendered":"

Niels C. Pedersen, DVM PhD<\/em>, November 28, 2022<\/p>\n\n\n\n

Originálny článok: Status of <\/a>FIP<\/a> treatment in 2022<\/p>\n\n\n\n

S potešením vám oznamujem, že som ukončil svoju poradenskú funkciu v SOCKFIP a oficiálne som sa stal členom predstavenstva SOCKFIP. Odráža to môj prechod z univerzitného do súkromného života, ale nebude to mať vplyv na moju oddanosť výskumu FIP. Dúfam, že toto priamejšie zapojenie pomôže SOCKFIP-u pri prechode na širšiu úlohu v otázkach týkajúcich sa zdravia mačiek okrem FIP.  Výskum FIP pokračuje na Kalifornskej univerzite v Davise, ako aj v iných inštitúciách po celom svete. Výskumné projekty týkajúce sa FIP na UC Davis sú zhrnuté v “ Srdečných pozdravoch SOCK FIP<\/a>“ z roku 2022. SOCKFIP prostredníctvom verejných darov naďalej poskytuje finančnú pomoc na takéto štúdie a ja poskytnem vedecké poznatky vždy, keď to bude potrebné.      <\/p>\n\n\n\n

Prial by som si, aby existovala licencovaná antivírusová liečba FIP u mačiek, ale ani úsilie mnohých jednotlivcov a skupín nedokázalo zmeniť súčasnú realitu. Preto je otázne, či sa legálne antivirotiká na FIP dostanú na trh v najbližších 2 až 5 rokoch, aj keby sa prekážky okamžite odstránili. Našťastie sa celosvetovo uvoľňujú obmedzenia všeobecného používania úzko súvisiacich humánnych liekov na COVID-19, čo umožňuje ich predpisovanie všetkými lekármi a širšie využitie v tejto oblasti. Úplné schválenie pre ľudí umožňuje ich použitie u zvierat za predpokladu, že potrebný liek je odvodený priamo od skutočného ľudského produktu. To by umožnilo legálne používať lieky vyrobené pre ľudí, ako sú remdesivir a molnupiravir (EIDD-2801), u zvierat, hoci za cenu humánnych liekov. Cieľom by stále mali byť lieky špeciálne licencované pre zvieratá a dostupné za veterinárnu, a nie medicínsku cenu. <\/p>\n\n\n\n

Čoraz viac veterinárnych lekárov už pomáha majiteľom pri liečbe. Aj naďalej ma však mrzí, že niektorí veterinári nepočuli o účinnej liečbe FIP, domnievajú sa, že publikované správy o liečbe sú falošné, alebo že získavanie liekov z neschválených trhov je také desivé, že ani nemôžu pomáhať pri liečbe, keď si ich majiteľ zakúpi. Chválim tých veterinárnych lekárov, ktorí akceptujú realitu liečby a spolupracujú s majiteľmi a ich mačkami s FIP.  <\/p>\n\n\n\n

Najvýznamnejším objavom po GS-441524 je použitie molnupiraviru (EIDD-2801) (Merck) ako druhej účinnej liečby FIP.  Molnupiravir je mimoriadne účinný aj pri liečbe mačiek, u ktorých sa vyvinula rezistencia na GS-441524, čo sú najčastejšie mačky, u ktorých sa počas liečby GS-441524 alebo po nej vyvinula neurologická FIP. V súčasnosti sa práve začínajú objavovať správy o jeho použití u mačiek, ktoré sú uverejnené na webovej stránke SOCK FIP. <\/p>\n\n\n\n

Domnievam sa, že veterinárni výskumníci by mali zvážiť niekoľko oblastí výskumu. Jedna oblasť sa týka bezpečnosti a účinnosti EIDD-1931 (beta-d-N4-hydroxycytidín), ktorý je biologicky aktívnou zložkou molnupiraviru, rovnako ako GS-441524 je aktívnou zložkou remdesiviru. Tento perorálne podávaný liek je predmetom výskumu už takmer pol storočia a nemal by byť viac patentovo chránený. Predbežný výskum na Kalifornskej univerzite v Davise naznačuje, že môže byť ešte účinnejší a bezpečnejší ako molnupiravir. Tiež sa domnievam, že perorálne podávaná zložka inhibítora proteáz (nirmatrelvir) Paxlovid (Pfizer) by sa mala testovať na neokulárne\/neneurologické prípady FIP. Nirmatrelvir sa rozkladá na jednoduchú chemickú modifikáciu GC373, aktívnu formu GC376. Paxlovid je široko dostupný a môžu ho ľahko predpisovať lekárnici aj lekári na všeobecnú liečbu COVID-19. Vďaka tomu by mal byť široko dostupný pre použitie veterinárnymi lekármi. Tiež sa domnievam, že by sa malo pokračovať v ďalšom výskume zameranom na hľadanie spôsobov, ako obmedziť infekciu FECV, a na pochopenie faktorov, ktoré potláčajú prirodzenú normálnu ochrannú imunitu voči mutantom FECV.  V tejto chvíli je zrejmé, že väčšina zdravých mačiek má silnú prirodzenú a získanú imunitu voči vírusom FIP. Aká je táto imunita<\/a> a ako môžu tieto poznatky prispieť k posilneniu imunity proti FIP?<\/p>\n","protected":false},"excerpt":{"rendered":"

Niels C. Pedersen, DVM PhD, November 28, 2022 Original article: Status of FIP treatment in 2022 I am pleased to announce that I have ended my advisory role at SOCKFIP and have officially become a SOCKFIP board member. It reflects my transition from university to private life, but will not affect my commitment to FIP research. \u2026 <\/p>\n

Continue reading "The Status of FIP Treatment and Prevention in 2022"<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":11393,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","footnotes":""},"categories":[191,188,1],"tags":[],"class_list":["post-11377","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-dr-pedersen","category-preverejnost","category-genart"],"featured_image_urls_v2":{"full":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/12\/pedersencat.jpg",1920,1080,false],"thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/12\/pedersencat-150x150.jpg",150,150,true],"medium":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/12\/pedersencat-300x169.jpg",300,169,true],"medium_large":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/12\/pedersencat-768x432.jpg",525,295,true],"large":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/12\/pedersencat-1024x576.jpg",525,295,true],"1536x1536":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/12\/pedersencat-1536x864.jpg",1536,864,true],"2048x2048":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/12\/pedersencat.jpg",1920,1080,false],"trp-custom-language-flag":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/12\/pedersencat-18x10.jpg",18,10,true],"twentyseventeen-featured-image":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/12\/pedersencat.jpg",1920,1080,false],"twentyseventeen-thumbnail-avatar":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/12\/pedersencat-100x100.jpg",100,100,true],"woocommerce_thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/12\/pedersencat-250x250.jpg",250,250,true],"woocommerce_single":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/12\/pedersencat-350x197.jpg",350,197,true],"woocommerce_gallery_thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/12\/pedersencat-100x100.jpg",100,100,true]},"post_excerpt_stackable_v2":"

Niels C. Pedersen, DVM PhD, November 28, 2022 Originálny článok: Status of FIP<\/a> treatment in 2022 S potešením vám oznamujem, že som ukončil svoju poradenskú funkciu v SOCKFIP a oficiálne som sa stal členom predstavenstva SOCKFIP. Odráža to môj prechod z univerzitného do súkromného života, ale nebude to mať vplyv na moju oddanosť výskumu FIP. Dúfam, že toto priamejšie zapojenie pomôže SOCKFIP-u pri prechode na širšiu úlohu v otázkach týkajúcich sa zdravia mačiek okrem FIP.  Výskum FIP pokračuje na Kalifornskej univerzite v Davise, ako aj v iných inštitúciách po celom svete. Výskumné projekty týkajúce sa FIP na UC Davis sú…<\/p>\n","category_list_v2":"Dr. Pedersen<\/a>, Pre verejnos\u0165<\/a>, V\u0161eobecn\u00e9 \u010dl\u00e1nky<\/a>","author_info_v2":{"name":"LM","url":"https:\/\/www.fipwarriors.eu\/en\/author\/starman\/"},"comments_num_v2":"0 comments","featured_image_src":"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/12\/pedersencat.jpg","author_info":{"display_name":"L. M.","author_link":"https:\/\/www.fipwarriors.eu\/en\/author\/starman\/"},"yoast_head":"\nStav lie\u010dby a prevencie FIP v roku 2022 - FIP Warriors CZ\/SK \u00ae<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.fipwarriors.eu\/en\/stav-liecby-a-prevencie-fip-v-roku-2022\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Stav lie\u010dby a prevencie FIP v roku 2022 - FIP Warriors CZ\/SK \u00ae\" \/>\n<meta property=\"og:description\" content=\"Niels C. Pedersen, DVM PhD, November 28, 2022 Originálny článok: Status of FIP treatment in 2022 S potešením vám oznamujem, že som ukončil svoju poradenskú funkciu v SOCKFIP a oficiálne som sa stal členom predstavenstva SOCKFIP. Odráža to môj prechod z univerzitného do súkromného života, ale nebude to mať vplyv na moju oddanosť výskumu FIP. … Continue reading "Stav liečby a prevencie FIP v roku 2022"\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.fipwarriors.eu\/en\/stav-liecby-a-prevencie-fip-v-roku-2022\/\" \/>\n<meta property=\"og:site_name\" content=\"FIP Warriors CZ\/SK \u00ae\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/groups\/fipczsk\" \/>\n<meta property=\"article:published_time\" content=\"2022-11-28T10:18:05+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-29T07:48:52+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2022\/12\/pedersencat.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"L. 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M.","author_link":"https:\/\/www.fipwarriors.eu\/en\/author\/starman\/"},"uagb_comment_info":0,"uagb_excerpt":"Niels C. Pedersen, DVM PhD, November 28, 2022 Originálny článok: Status of FIP treatment in 2022 S potešením vám oznamujem, že som ukončil svoju poradenskú funkciu v SOCKFIP a oficiálne som sa stal členom predstavenstva SOCKFIP. Odráža to môj prechod z univerzitného do súkromného života, ale nebude to mať vplyv na moju oddanosť výskumu FIP.…","_links":{"self":[{"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/posts\/11377","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/comments?post=11377"}],"version-history":[{"count":1,"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/posts\/11377\/revisions"}],"predecessor-version":[{"id":11668,"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/posts\/11377\/revisions\/11668"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/media\/11393"}],"wp:attachment":[{"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/media?parent=11377"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/categories?post=11377"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/tags?post=11377"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}