{"id":12196,"date":"2023-10-03T22:15:27","date_gmt":"2023-10-03T20:15:27","guid":{"rendered":"https:\/\/www.fipwarriors.eu\/?p=12196"},"modified":"2023-10-03T22:52:35","modified_gmt":"2023-10-03T20:52:35","slug":"mysterious-new-stone-type-in-cats","status":"publish","type":"post","link":"https:\/\/www.fipwarriors.eu\/en\/mysterious-new-stone-type-in-cats\/","title":{"rendered":"A mysterious new type of stone in cats"},"content":{"rendered":"

Original article: Mysterious New Stone Type In Cats<\/a><\/p>\n\n\n

\n
\"Krátka<\/a>
Figure 1: Feline uroliths<\/figcaption><\/figure>\n<\/div>\n\n\n

Between January and April 2023, the Urolite Center in Minnesota received three shipments of atypical stones (Figure 1). All three samples were obtained from cats. All three cats were under 1 year old. Cats came from North and South America. In each case, the infrared spectrographic pattern of the stones was identical. Urinary stones usually contain large amounts of phosphorus, calcium and magnesium. In these cases, electron dispersion spectroscopy revealed a high proportion of nitrogen, carbon and oxygen.<\/p>\n\n\n\n

Mystery solved. When asked about their medical history, all three cats were diagnosed with feline infectious peritonitis. All three were treated with either Remdesivir or its metabolite GS-441524. We requested samples of their antiviral drugs for analysis. The antiviral drugs were spectrographically identical (Figure 2). The stones were composed of GS-441524.<\/p>\n\n\n

\n
\"\"<\/a>
Figure 2: FT-IR spectroscopy of urinary stone of patient and reference sample GS-441524<\/figcaption><\/figure>\n<\/div>\n\n\n

After administration, GS-441524 is excreted primarily in the urine. Although GS-441524 is very soluble in organic solvents such as DMSO (10-59 mg\/ml), it is poorly soluble in aqueous solutions such as water (0.0004 to 0.1 mg\/ml). Its limited solubility makes GS-441524 a prime candidate for stone formation. Observation of urinary symptoms in cats receiving Remdesivir or GS-441524 is an indication to look for stones. Observation of atypical crystalluria or uroliths may be an indication to limit the dose of the drug (if possible) and increase water consumption to minimize stone formation.<\/p>\n\n\n\n

Passhaei Y. Analytical methods for the determination of Remdesivir as a promising antiviral candidate drug for the COVID-19 pandemic. Drug Discoveries and Therapeutics. 2020;14:273-281<\/a><\/p>\n\n\n\n

Wei D. et al. Potency and pharmacokinetics of GS-441524 derivatives against SARS-CoV-2. Bioorg Med Chem. 2021;46:116364<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Original article: Mysterious New Stone Type In Cats Between January and April 2023, the Urolite Center in Minnesota received three shipments of atypical stones (Figure 1). All three samples were obtained from cats. All three cats were under 1 year old. Cats came from North and South America. In any case, the infrared spectrographic pattern was... <\/p>\n

Continue reading "Mysterious new type of stone in cats"<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":12207,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","footnotes":""},"categories":[187,188,190,1],"tags":[],"class_list":["post-12196","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-odborne","category-preverejnost","category-preklady","category-genart"],"featured_image_urls_v2":{"full":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2023\/10\/cat-bed-fhd.jpg",1920,1080,false],"thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2023\/10\/cat-bed-fhd-150x150.jpg",150,150,true],"medium":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2023\/10\/cat-bed-fhd-300x169.jpg",300,169,true],"medium_large":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2023\/10\/cat-bed-fhd-768x432.jpg",525,295,true],"large":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2023\/10\/cat-bed-fhd-1024x576.jpg",525,295,true],"1536x1536":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2023\/10\/cat-bed-fhd-1536x864.jpg",1536,864,true],"2048x2048":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2023\/10\/cat-bed-fhd.jpg",1920,1080,false],"trp-custom-language-flag":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2023\/10\/cat-bed-fhd-18x10.jpg",18,10,true],"twentyseventeen-featured-image":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2023\/10\/cat-bed-fhd.jpg",1920,1080,false],"twentyseventeen-thumbnail-avatar":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2023\/10\/cat-bed-fhd-100x100.jpg",100,100,true],"woocommerce_thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2023\/10\/cat-bed-fhd-250x250.jpg",250,250,true],"woocommerce_single":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2023\/10\/cat-bed-fhd-350x197.jpg",350,197,true],"woocommerce_gallery_thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2023\/10\/cat-bed-fhd-100x100.jpg",100,100,true]},"post_excerpt_stackable_v2":"

Originálny článok: Mysterious New Stone Type In Cats Obrázok 1: Mačacie urolity V období od januára do apríla 2023 dostalo Urolitové centrum v Minnesote tri zásielky atypických kameňov (obrázok 1). Všetky tri vzorky boli získané od mačiek. Všetky tri mačky boli mladšie ako 1 rok. Mačky pochádzali zo Severnej a Južnej Ameriky. V každom prípade bol infračervený spektrografický vzor kameňov identický. Močové kamene zvyčajne obsahujú veľké množstvo fosforu, vápnika a horčíka. V týchto prípadoch sa elektrónovou disperznou spektroskopiou zistil vysoký podiel dusíka, uhlíka a kyslíka. Záhada vyriešená. Keď sme sa opýtali na ich anamnézu, všetkým trom mačkám bola diagnostikovaná mačacia…<\/p>\n","category_list_v2":"Odborn\u00e9<\/a>, Pre verejnos\u0165<\/a>, Preklady<\/a>, V\u0161eobecn\u00e9 \u010dl\u00e1nky<\/a>","author_info_v2":{"name":"LM","url":"https:\/\/www.fipwarriors.eu\/en\/author\/starman\/"},"comments_num_v2":"0 comments","featured_image_src":"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2023\/10\/cat-bed-fhd.jpg","author_info":{"display_name":"L. M.","author_link":"https:\/\/www.fipwarriors.eu\/en\/author\/starman\/"},"yoast_head":"\nZ\u00e1hadn\u00fd nov\u00fd typ kame\u0148a u ma\u010diek - FIP Warriors CZ\/SK \u00ae<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.fipwarriors.eu\/en\/mysterious-new-stone-type-in-cats\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Z\u00e1hadn\u00fd nov\u00fd typ kame\u0148a u ma\u010diek - FIP Warriors CZ\/SK \u00ae\" \/>\n<meta property=\"og:description\" content=\"Originálny článok: Mysterious New Stone Type In Cats V období od januára do apríla 2023 dostalo Urolitové centrum v Minnesote tri zásielky atypických kameňov (obrázok 1). Všetky tri vzorky boli získané od mačiek. Všetky tri mačky boli mladšie ako 1 rok. Mačky pochádzali zo Severnej a Južnej Ameriky. 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V každom prípade bol infračervený spektrografický vzor … Continue reading "Záhadný nový typ kameňa u mačiek"","og_url":"https:\/\/www.fipwarriors.eu\/en\/mysterious-new-stone-type-in-cats\/","og_site_name":"FIP Warriors CZ\/SK \u00ae","article_publisher":"https:\/\/www.facebook.com\/groups\/fipczsk","article_published_time":"2023-10-03T20:15:27+00:00","article_modified_time":"2023-10-03T20:52:35+00:00","og_image":[{"width":1920,"height":1080,"url":"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2023\/10\/cat-bed-fhd.jpg","type":"image\/jpeg"}],"author":"L. M.","twitter_card":"summary_large_image","twitter_misc":{"Written by":"L. M.","Estimated reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.fipwarriors.eu\/mysterious-new-stone-type-in-cats\/#article","isPartOf":{"@id":"https:\/\/www.fipwarriors.eu\/mysterious-new-stone-type-in-cats\/"},"author":{"name":"L. 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M.","author_link":"https:\/\/www.fipwarriors.eu\/en\/author\/starman\/"},"uagb_comment_info":0,"uagb_excerpt":"Originálny článok: Mysterious New Stone Type In Cats V období od januára do apríla 2023 dostalo Urolitové centrum v Minnesote tri zásielky atypických kameňov (obrázok 1). Všetky tri vzorky boli získané od mačiek. Všetky tri mačky boli mladšie ako 1 rok. Mačky pochádzali zo Severnej a Južnej Ameriky. V každom prípade bol infračervený spektrografický vzor…","_links":{"self":[{"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/posts\/12196","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/comments?post=12196"}],"version-history":[{"count":10,"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/posts\/12196\/revisions"}],"predecessor-version":[{"id":12212,"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/posts\/12196\/revisions\/12212"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/media\/12207"}],"wp:attachment":[{"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/media?parent=12196"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/categories?post=12196"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/tags?post=12196"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}