{"id":12556,"date":"2024-09-26T13:03:00","date_gmt":"2024-09-26T11:03:00","guid":{"rendered":"https:\/\/www.fipwarriors.eu\/?p=12556"},"modified":"2025-07-24T14:35:40","modified_gmt":"2025-07-24T12:35:40","slug":"otvorena-klinicka-studia-peroralne-podavaneho-molnupiraviru-ako-liecby-prvej-volby-prirodzene-sa-vyskytujucej-efuzivnej-infekcnej-peritonitidy-maciek","status":"publish","type":"post","link":"https:\/\/www.fipwarriors.eu\/en\/otvorena-klinicka-studia-peroralne-podavaneho-molnupiraviru-ako-liecby-prvej-volby-prirodzene-sa-vyskytujucej-efuzivnej-infekcnej-peritonitidy-maciek\/","title":{"rendered":"Open-label clinical trial of orally administered molnupiravir as first-line treatment for naturally occurring feline effusive infectious peritonitis"},"content":{"rendered":"

Krystle L. Reagan, Terza Brostoff, Jully Pires, Amy Rose, Diego Castillo, Brian G. Murphy<\/p>\n\n\n\n

26.9.2024<\/p>\n\n\n\n

Pôvodný celý článok:
Open label clinical trial of orally administered molnupiravir as a first-line treatment for naturally occurring effusive feline infectious peritonitis<\/a><\/p>\n\n\n\n

Abstrakt<\/h2><\/div>\n\n\n\n

Základné informácie<\/strong>
Pred objavením účinných antivírusových liekov bola infekčná peritonitída mačiek (FIP<\/a>) smrteľnou chorobou mačiek. Bolo identifikovaných viacero antivírusových liečebných postupov, ale je potrebná optimalizácia liečebných protokolov.<\/p>\n\n\n\n

Cieľ<\/strong>
Vyhodnotiť účinnosť PO molnupiraviru (MPV; EIDD-2801) pri liečbe efuzívnej FIP.<\/p>\n\n\n\n

Zvieratá<\/strong>
Desať mačiek s prirodzene sa vyskytujúcou efuzívnou FIP a 10 mačiek z kontrolnej skupiny liečených PO GS-441524.<\/p>\n\n\n\n

Metódy<\/strong>
Prospektívna, otvorená, longitudinálna, porovnávacia štúdia s referenčnou kontrolnou skupinou. Do štúdie bolo zaradených desať mačiek s FIP, ktoré boli liečené PO MPV (10–15 mg\/kg PO q12h) počas 84 dní. Mačky boli hodnotené v 0., 6. a 16. týždni a bol stanovený podiel mačiek v klinickej remisii v 16. týždni. Prežívanie a klinicko-patologické charakteristiky boli porovnané s mačkami z kontrolnej skupiny s efuzívnou FIP, ktoré boli liečené PO GS-441524.<\/p>\n\n\n\n

Výsledky<\/strong>
Osem z 10 mačiek liečených MPV prežilo a bolo v remisii po 16 týždňoch. Dve mačky, ktoré neprežili, uhynuli v prvých 24 hodinách liečby. Neboli pozorované žiadne nežiaduce účinky, ktoré by si vyžadovali prerušenie liečby. Prežívanie mačiek liečených PO MPV nebolo horšie ako u historickej kontrolnej skupiny mačiek liečených PO GS-441524 (prežilo 5\/9 [55 %]), s rozdielom v prežívaní 25 % (90 % interval spoľahlivosti, −9,3 % až 59,3 %). Klinickopatologické charakteristiky spojené s FIP sa počas štúdie normalizovali a pri porovnaní mačiek liečených MPV a GS-441524 neboli pozorované žiadne rozdiely v klinickopatologických údajoch v jednotlivých časových bodoch štúdie.<\/p>\n\n\n\n

Závery a klinický význam<\/strong>
Molnupiravir je účinná antivírusová liečba efuzívnej FIP.<\/p>\n\n\n\n

<\/p>\n\n\n\n

Celá štúdia je k dispozícii v angličtine na https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11586577\/<\/a><\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Clinical trial of treatment of effusive FIP with orally administered molnupiravir at UC Davis.<\/p>","protected":false},"author":1,"featured_media":12559,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","footnotes":""},"categories":[189,193],"tags":[271],"class_list":["post-12556","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-abstrakt","category-klinicke-studie","tag-eidd"],"featured_image_urls_v2":{"full":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2025\/07\/cat-molnu-abstract.jpg",1920,1080,false],"thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2025\/07\/cat-molnu-abstract-150x150.jpg",150,150,true],"medium":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2025\/07\/cat-molnu-abstract-300x169.jpg",300,169,true],"medium_large":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2025\/07\/cat-molnu-abstract-768x432.jpg",525,295,true],"large":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2025\/07\/cat-molnu-abstract-1024x576.jpg",525,295,true],"1536x1536":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2025\/07\/cat-molnu-abstract-1536x864.jpg",1536,864,true],"2048x2048":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2025\/07\/cat-molnu-abstract.jpg",1920,1080,false],"trp-custom-language-flag":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2025\/07\/cat-molnu-abstract-18x10.jpg",18,10,true],"twentyseventeen-featured-image":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2025\/07\/cat-molnu-abstract.jpg",1920,1080,false],"twentyseventeen-thumbnail-avatar":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2025\/07\/cat-molnu-abstract-100x100.jpg",100,100,true],"woocommerce_thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2025\/07\/cat-molnu-abstract-250x250.jpg",250,250,true],"woocommerce_single":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2025\/07\/cat-molnu-abstract-350x197.jpg",350,197,true],"woocommerce_gallery_thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2025\/07\/cat-molnu-abstract-100x100.jpg",100,100,true]},"post_excerpt_stackable_v2":"

Klinická štúdia liečby efuzívnej FIP<\/a> perorálne podávaným molnupiravirom na UC Davis.<\/p>\n","category_list_v2":"Abstrakty<\/a>, Klinick\u00e9 \u0161t\u00fadie<\/a>","author_info_v2":{"name":"LM","url":"https:\/\/www.fipwarriors.eu\/en\/author\/starman\/"},"comments_num_v2":"0 comments","featured_image_src":"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2025\/07\/cat-molnu-abstract.jpg","author_info":{"display_name":"L. 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