{"id":12568,"date":"2024-07-18T13:59:00","date_gmt":"2024-07-18T11:59:00","guid":{"rendered":"https:\/\/www.fipwarriors.eu\/?p=12568"},"modified":"2025-07-24T14:41:00","modified_gmt":"2025-07-24T12:41:00","slug":"gs-441524-a-molnupiravir-su-podobne-ucinne-pri-liecbe-maciek-s-infekcnou-peritonitidou-maciek","status":"publish","type":"post","link":"https:\/\/www.fipwarriors.eu\/en\/gs-441524-a-molnupiravir-su-podobne-ucinne-pri-liecbe-maciek-s-infekcnou-peritonitidou-maciek\/","title":{"rendered":"GS-441524 and molnupiravir are similarly effective in treating cats with feline infectious peritonitis."},"content":{"rendered":"

Pôvodný článok:
GS-441524 and molnupiravir are similarly effective for the treatment of cats with feline infectious peritonitis<\/a><\/p>\n\n\n\n

Hoci nie sú registrované pre infekčnú peritonitídu mačiek (FIP<\/a>) v Japonsku, nukleozidové analógy preukázali účinnosť a od januára 2020 ich ponúkame majiteľom mačiek s FIP v našej klinike. Cieľom tejto štúdie bolo preskúmať výsledky u mačiek s FIP, ktoré užívali GS-441524 alebo molnupiravir. Diagnóza FIP bola založená na klinických príznakoch, výsledkoch laboratórnych testov a prítomnosti RNA<\/a> mačacieho koronavírusu v krvi alebo výpotku. Po poskytnutí ústnych a písomných informácií bola majiteľom mačiek s predpokladanou diagnózou FIP ponúknutá antivírusová liečba komerčne dostupným GS-441524 od júna 2020 a buď GS-441524, alebo molnupiravirom od januára 2022. Dávkovanie bolo 12,5–25 mg\/kg\/deň pre GS-441524 a 20–40 mg\/kg\/deň pre molnupiravir, v závislosti od prítomnosti výpotku a neurologických a\/alebo očných príznakov, a pokračovalo sa v ňom 84 dní. Celkovo bolo liečených 118 mačiek s FIP (76 s výpotkom), 59 s GS-4421524 a 59 s molnupiravirom. Dvadsať mačiek zomrelo, 12\/59 (20,3 %) v skupine GS-441524 a 8\/59 (13,6 %) v skupine s molnupiravirom (p = 0,326), pričom väčšina úmrtí nastala v priebehu prvých 10 dní od začatia liečby. U preživších sa neurologické a očné príznaky vyriešili u všetkých okrem jednej mačky, ktorá mala pretrvávajúce záchvaty. Zo mačiek, ktoré dokončili liečbu, dosiahlo remisiu 48\/48 v skupine GS-441524 a 51\/52 v skupine molnupiravir. Laboratórne parametre sa normalizovali do 6 až 7 týždňov od zahájenia podávania lieku. Nežiaduce účinky, ako napríklad abnormality pečeňových funkcií, boli prechodné a vyriešili sa bez špecifického zásahu. Naše údaje naznačujú, že GS-441524 a molnupiravir vykazujú podobné účinky a bezpečnosť u mačiek s FIP.<\/p>\n\n\n\n

Celý článok nájdete v angličtine na https:\/\/doi.org\/10.3389\/fvets.2024.1422408<\/p>\n","protected":false},"excerpt":{"rendered":"

Experience with the treatment of FIP with GS-441524 and molnupiravir in Japan. The result is that both agents are found to be similarly effective in the treatment of FIP.<\/p>","protected":false},"author":1,"featured_media":12571,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","footnotes":""},"categories":[189,193],"tags":[271],"class_list":["post-12568","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-abstrakt","category-klinicke-studie","tag-eidd"],"featured_image_urls_v2":{"full":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2025\/07\/cat-japan-FHD.jpg",1920,1080,false],"thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2025\/07\/cat-japan-FHD-150x150.jpg",150,150,true],"medium":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2025\/07\/cat-japan-FHD-300x169.jpg",300,169,true],"medium_large":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2025\/07\/cat-japan-FHD-768x432.jpg",525,295,true],"large":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2025\/07\/cat-japan-FHD-1024x576.jpg",525,295,true],"1536x1536":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2025\/07\/cat-japan-FHD-1536x864.jpg",1536,864,true],"2048x2048":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2025\/07\/cat-japan-FHD.jpg",1920,1080,false],"trp-custom-language-flag":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2025\/07\/cat-japan-FHD-18x10.jpg",18,10,true],"twentyseventeen-featured-image":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2025\/07\/cat-japan-FHD.jpg",1920,1080,false],"twentyseventeen-thumbnail-avatar":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2025\/07\/cat-japan-FHD-100x100.jpg",100,100,true],"woocommerce_thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2025\/07\/cat-japan-FHD-250x250.jpg",250,250,true],"woocommerce_single":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2025\/07\/cat-japan-FHD-350x197.jpg",350,197,true],"woocommerce_gallery_thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2025\/07\/cat-japan-FHD-100x100.jpg",100,100,true]},"post_excerpt_stackable_v2":"

Skúsenosti s liečbou FIP<\/a> pomocou GS-441524 a molnupiravirom v Japonsku. Výsledkom je zistenie, že obidve látky sú podobne účinné pri liečbe FIP.<\/p>\n","category_list_v2":"Abstrakty<\/a>, Klinick\u00e9 \u0161t\u00fadie<\/a>","author_info_v2":{"name":"LM","url":"https:\/\/www.fipwarriors.eu\/en\/author\/starman\/"},"comments_num_v2":"0 comments","featured_image_src":"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2025\/07\/cat-japan-FHD.jpg","author_info":{"display_name":"L. M.","author_link":"https:\/\/www.fipwarriors.eu\/en\/author\/starman\/"},"yoast_head":"\nGS-441524 a molnupiravir s\u00fa podobne \u00fa\u010dinn\u00e9 pri lie\u010dbe ma\u010diek s infek\u010dnou peritonit\u00eddou ma\u010diek. - FIP Warriors CZ\/SK \u00ae<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.fipwarriors.eu\/en\/gs-441524-a-molnupiravir-su-podobne-ucinne-pri-liecbe-maciek-s-infekcnou-peritonitidou-maciek\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"GS-441524 a molnupiravir s\u00fa podobne \u00fa\u010dinn\u00e9 pri lie\u010dbe ma\u010diek s infek\u010dnou peritonit\u00eddou ma\u010diek. - FIP Warriors CZ\/SK \u00ae\" \/>\n<meta property=\"og:description\" content=\"Skúsenosti s liečbou FIP pomocou GS-441524 a molnupiravirom v Japonsku. Výsledkom je zistenie, že obidve látky sú podobne účinné pri liečbe FIP.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.fipwarriors.eu\/en\/gs-441524-a-molnupiravir-su-podobne-ucinne-pri-liecbe-maciek-s-infekcnou-peritonitidou-maciek\/\" \/>\n<meta property=\"og:site_name\" content=\"FIP Warriors CZ\/SK \u00ae\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/groups\/fipczsk\" \/>\n<meta property=\"article:published_time\" content=\"2024-07-18T11:59:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-07-24T12:41:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2025\/07\/cat-japan-FHD.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"L. M.\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"L. M.\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.fipwarriors.eu\\\/gs-441524-a-molnupiravir-su-podobne-ucinne-pri-liecbe-maciek-s-infekcnou-peritonitidou-maciek\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.fipwarriors.eu\\\/gs-441524-a-molnupiravir-su-podobne-ucinne-pri-liecbe-maciek-s-infekcnou-peritonitidou-maciek\\\/\"},\"author\":{\"name\":\"L. 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