{"id":1524,"date":"2020-03-31T09:07:14","date_gmt":"2020-03-31T07:07:14","guid":{"rendered":"https:\/\/www.fipwarriors.eu\/?p=1524"},"modified":"2023-03-29T09:50:26","modified_gmt":"2023-03-29T07:50:26","slug":"dr-pedersen-o-vztahu-medzi-remdesivirom-a-gs-441524","status":"publish","type":"post","link":"https:\/\/www.fipwarriors.eu\/en\/dr-pedersen-o-vztahu-medzi-remdesivirom-a-gs-441524\/","title":{"rendered":"Dr. Pedersen on the relationship between Remdesivir and GS441524"},"content":{"rendered":"

Originál článku: SOCKFIP<\/a><\/em>

Vážení veterinári, majitelia mačiek a verejnosť,

Stále som dotazovaný na vzťah medzi GS-441524 a veľmi nádejnou liečbou pre Covid-19 – Remdesivirom. GS-441524 je biologicky aktívna zložka Remdesiviru a na celom svete sa bežne používa na bezpečnú a efektívnu liečbu mačacej infekčnej peritonitídy (FIP<\/a>) už viac ako 18 mesiacov. FIP je bežné a fatálne koronavírové ochorenie mačiek. GS-441424 a Remdesivir sú takmer identické lieky. Remdesivir je forma GS-441424, ktorú sa spoločnosť Gilead Sciences rozhodla používať u ľudí pre liečbu COVID-19, a momentálne prebiehajú klinické testy v Číne, USA a niekoľkých ďalších krajinách. Remdesivir je tzv. prodrug. Prodrug je transformovaný infikovanými bunkami na aktívnu zložku, ktorá je v tomto prípade GS-441524 s pridaním jednej fosfátovej skupiny (t.j.GS-5734). Vedci z Gileadu mierne zmenili GS-5734, aby chránili pridanú fosfátovú skupinu a umožnili absorpciu do buniek. Táto forma GS-441524 je známa ako Remdesivir. Po preniknutí do bunky jej enzýmy odstránia ochranu, čím sa získa GS-5734. GS-5734 sa ďalej v bunkách aktivuje pridaním dvoch ďalších fosfátov a vzniká trifosfátovová forma GS-441524. Toto je molekula, ktorá inhibuje produkciu vírusovej RNA<\/a>. GS-441524 sme sa rozhodli použiť na liečbu FIP preto, lebo mal rovnaké antivirotické vlastnosti ako Remdesivir a v tom čase Gilead Sciences nepočítal s jeho použitím u ľudí. GS-441524 je taktiež omnoho lacnejší ako Remdesivir. Preto nebol zjavný konflikt medzi použitím jednej formy pre mačky a inej formy pre človeka. Gilead však prišiel k presvedčeniu, že náš výskum mačiek by ovplyvnil schválenie Remdesiviru pre použitie v humánnej medicíne a odmietol povoliť GS-441524 pre liečbu zvierat. Toto odmietnutie spojené so zúfalou potrebou liečby FIP na celom svete viedlo k vzniku čínskeho čierneho trhu s GS-441524. FIP je významným problémom domácich mačiek v Číne a čínski majitelia mačiek sa dožadovali liečby FIP ešte zúfalejší ako majitelia v iných krajinách. Prvé práce opisujúce liečbu FIP pomocou GS-441524 boli uverejnené v rokoch 2018 a 2019 a odvtedy liečbu absolvovali tisíce mačiek. Napriek týmto skúsenostiam lekárska obec, vrátane výskumných pracovníkov, zjavne nevedela o použití GS-441524 na liečbu FIP a jej vzťahu k Remdesiviru. Veterinári majú pritom značné ale nedocenené skúsenosti s koronavírusmi, koronavírusovými chorobami a vakcínami ošípaných, teliat a hydiny. Fretky tiež trpia závažným ochorením podobným FIP spôsobeným vlastným druhom koronavírusu. Čo sa stane s GS-441524 pre mačky, ak sa preukáže, že Remdesivir je bezpečný a účinný pri liečbe Covid-19? GS-441524 je prvým kritickým krokom vo výrobe Remdesiviru a je logické predpokladať, že povedie k existencii konkurencie v jeho použití pre mačky a ľuďí. Pozitívne je, že celosvetové schválenie Remdesiviru môže tiež pomôcť zmeniť názor proti udeleniu práv na použitie GS-441524 u zvierat. Ak by bol Remdesivir schválený na humánne použitie (hoci aj v prípade neschválenia samotného GS-441524), mohol by sa stať legálne dostupným aj pre použitie vo veterinárnej medicíne. Bezpečnosť a účinnosť Remdesiviru pre liečbu FIP však ešte nebola preskúmaná.

-Niels C. Pedersen, DVM, PhD, Škola veterinárnej medicíny, UC Davis.. <\/p>\n","protected":false},"excerpt":{"rendered":"

Niels Pedersen? dr. Pedersen explains in an understandable way the differences but also the common features of Remdesivir and GS-441524.<\/p>","protected":false},"author":1,"featured_media":1557,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","footnotes":""},"categories":[191,188,190],"tags":[178,180,179],"class_list":["post-1524","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-dr-pedersen","category-preverejnost","category-preklady","tag-dr-pedersen","tag-gs441524","tag-remdesivir"],"featured_image_urls_v2":{"full":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2020\/03\/covid19b.jpg",2000,1029,false],"thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2020\/03\/covid19b-150x150.jpg",150,150,true],"medium":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2020\/03\/covid19b-300x154.jpg",300,154,true],"medium_large":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2020\/03\/covid19b-768x395.jpg",525,270,true],"large":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2020\/03\/covid19b-1024x527.jpg",525,270,true],"1536x1536":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2020\/03\/covid19b-1536x790.jpg",1536,790,true],"2048x2048":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2020\/03\/covid19b.jpg",2000,1029,false],"trp-custom-language-flag":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2020\/03\/covid19b.jpg",18,9,false],"twentyseventeen-featured-image":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2020\/03\/covid19b.jpg",2000,1029,false],"twentyseventeen-thumbnail-avatar":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2020\/03\/covid19b-100x100.jpg",100,100,true],"woocommerce_thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2020\/03\/covid19b-250x250.jpg",250,250,true],"woocommerce_single":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2020\/03\/covid19b-350x180.jpg",350,180,true],"woocommerce_gallery_thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2020\/03\/covid19b-100x100.jpg",100,100,true]},"post_excerpt_stackable_v2":"

Niels Pedersen ? Dr. Pedersen vysvetľuje zrozumiteľným spôsobom rozdiely ale aj spoločné vlastnosti Remdesiviru a GS-441524.<\/p>\n","category_list_v2":"Dr. Pedersen<\/a>, Pre verejnos\u0165<\/a>, Preklady<\/a>","author_info_v2":{"name":"LM","url":"https:\/\/www.fipwarriors.eu\/en\/author\/starman\/"},"comments_num_v2":"0 comments","featured_image_src":"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2020\/03\/covid19b.jpg","author_info":{"display_name":"L. 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