{"id":3824,"date":"2020-11-13T20:49:41","date_gmt":"2020-11-13T19:49:41","guid":{"rendered":"https:\/\/www.fipwarriors.eu\/?p=3824"},"modified":"2023-03-29T09:50:22","modified_gmt":"2023-03-29T07:50:22","slug":"preklinicky-inhibitor-gs441524-v-kombinacii-s-gc376-ucinne-potlacal-mnozenie-sars-cov-2-v-dychacom-trakte-mysi","status":"publish","type":"post","link":"https:\/\/www.fipwarriors.eu\/en\/preklinicky-inhibitor-gs441524-v-kombinacii-s-gc376-ucinne-potlacal-mnozenie-sars-cov-2-v-dychacom-trakte-mysi\/","title":{"rendered":"The preclinical inhibitor GS441524 in combination with GC376 effectively suppressed SARS-CoV-2 proliferation in the respiratory tract of mice."},"content":{"rendered":"

Celý článok nájdete na serveri biorxiv.org<\/a>;
13.11.2020.<\/p>\n\n\n\n

Abstrakt<\/h3>\n\n\n\n

Bezprecedentná pandémia koronavírusovej choroby z roku 2019 (COVID-19) spôsobená vírusom ťažkého akútneho respiračného syndrómu druhého typu (SARS-CoV-2) predstavuje vážnu hrozbu pre verejné zdravie na celom svete. Naliehavo je potrebné vyvinúť účinné terapie proti SARS-CoV-2. Hodnotili sme antivírusovú aktivitu pôvodného nukleotidového analógu remdesiviru, GS441524, ktorý cieli na enzým RNA<\/a>-dependentnej RNA polymerázy, a inhibítoru proteázy GC376, cieleného na proteázu SARS-CoV 2 u infikovanej myši. Naše výsledky ukázali, že GS441524 účinne blokoval proliferáciu (množenie) SARS-CoV-2 v horných a dolných dýchacích cestách pri kombinovanej intranazálnou (i.n.) a intramuskulárnou (i.m.) terapii. Účinnosť vysokej dávky GC376 (i.m. alebo i.n. a i.m.) bola slabšia ako GS441524. Je ale pozoruhodné, že kombinovaná aplikácia GS441524 spolu s GC376 v nízkych dávkach mohla účinne chrániť myši pred infekciou SARS-CoV-2 pri i.n. alebo i.n. a i.m. liečbe. Ďalej sme zistili, že farmakokinetické vlastnosti GS441524 sú lepšie ako GC376, a kombinovaná aplikácia GC376 a GS441524 mala synergický účinok. Naše zistenia budú využité pre ďalšie hodnotenie kombinovanej aplikácie GC376 a GS441524 v budúcich klinických štúdiách.<\/p>\n","protected":false},"excerpt":{"rendered":"

Celý článok nájdete na serveri biorxiv.org; 13.11.2020. Abstrakt Bezprecedentná pandémia koronavírusovej choroby z roku 2019 (COVID-19) spôsobená vírusom ťažkého akútneho respiračného syndrómu druhého typu (SARS-CoV-2) predstavuje vážnu hrozbu pre verejné zdravie na celom svete. Naliehavo je potrebné vyvinúť účinné terapie proti SARS-CoV-2. Hodnotili sme antivírusovú aktivitu pôvodného nukleotidového analógu remdesiviru, GS441524, ktorý cieli na enzým … <\/p>\n

Continue reading "Preklinický inhibítor<\/a> GS441524 v kombinácii s GC376 účinne potláčal množenie SARS-CoV-2 v dýchacom trakte myší."<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":3825,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","footnotes":""},"categories":[189,187],"tags":[],"class_list":["post-3824","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-abstrakt","category-odborne"],"featured_image_urls_v2":{"full":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/01\/mers-virus-coronavirus-crop.jpg",1920,989,false],"thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/01\/mers-virus-coronavirus-crop-150x150.jpg",150,150,true],"medium":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/01\/mers-virus-coronavirus-crop-300x155.jpg",300,155,true],"medium_large":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/01\/mers-virus-coronavirus-crop-768x396.jpg",525,271,true],"large":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/01\/mers-virus-coronavirus-crop-1024x527.jpg",525,270,true],"1536x1536":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/01\/mers-virus-coronavirus-crop-1536x791.jpg",1536,791,true],"2048x2048":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/01\/mers-virus-coronavirus-crop.jpg",1920,989,false],"trp-custom-language-flag":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/01\/mers-virus-coronavirus-crop-16x8.jpg",16,8,true],"twentyseventeen-featured-image":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/01\/mers-virus-coronavirus-crop.jpg",1920,989,false],"twentyseventeen-thumbnail-avatar":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/01\/mers-virus-coronavirus-crop-100x100.jpg",100,100,true],"woocommerce_thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/01\/mers-virus-coronavirus-crop-250x250.jpg",250,250,true],"woocommerce_single":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/01\/mers-virus-coronavirus-crop-350x180.jpg",350,180,true],"woocommerce_gallery_thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/01\/mers-virus-coronavirus-crop-100x100.jpg",100,100,true]},"post_excerpt_stackable_v2":"

Celý článok nájdete na serveri biorxiv.org; 13.11.2020. Abstrakt Bezprecedentná pandémia koronavírusovej choroby z roku 2019 (COVID-19) spôsobená vírusom ťažkého akútneho respiračného syndrómu druhého typu (SARS-CoV-2) predstavuje vážnu hrozbu pre verejné zdravie na celom svete. Naliehavo je potrebné vyvinúť účinné terapie proti SARS-CoV-2. Hodnotili sme antivírusovú aktivitu pôvodného nukleotidového analógu remdesiviru, GS441524, ktorý cieli na enzým RNA-dependentnej RNA polymerázy, a inhibítoru proteázy GC376, cieleného na proteázu SARS-CoV 2 u infikovanej myši. Naše výsledky ukázali, že GS441524 účinne blokoval proliferáciu (množenie) SARS-CoV-2 v horných a dolných dýchacích cestách pri kombinovanej intranazálnou (i.n.) a intramuskulárnou (i.m.) terapii. Účinnosť vysokej dávky GC376 (i.m. alebo…<\/p>\n","category_list_v2":"Abstrakty<\/a>, Odborn\u00e9<\/a>","author_info_v2":{"name":"LM","url":"https:\/\/www.fipwarriors.eu\/en\/author\/starman\/"},"comments_num_v2":"0 comments","featured_image_src":"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/01\/mers-virus-coronavirus-crop.jpg","author_info":{"display_name":"L. M.","author_link":"https:\/\/www.fipwarriors.eu\/en\/author\/starman\/"},"yoast_head":"\nPreklinick\u00fd inhib\u00edtor GS441524 v kombin\u00e1cii s GC376 \u00fa\u010dinne potl\u00e1\u010dal mno\u017eenie SARS-CoV-2 v d\u00fdchacom trakte my\u0161\u00ed. - FIP Warriors CZ\/SK \u00ae<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.fipwarriors.eu\/en\/preklinicky-inhibitor-gs441524-v-kombinacii-s-gc376-ucinne-potlacal-mnozenie-sars-cov-2-v-dychacom-trakte-mysi\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preklinick\u00fd inhib\u00edtor GS441524 v kombin\u00e1cii s GC376 \u00fa\u010dinne potl\u00e1\u010dal mno\u017eenie SARS-CoV-2 v d\u00fdchacom trakte my\u0161\u00ed. - FIP Warriors CZ\/SK \u00ae\" \/>\n<meta property=\"og:description\" content=\"Celý článok nájdete na serveri biorxiv.org; 13.11.2020. 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Hodnotili sme antivírusovú aktivitu pôvodného nukleotidového analógu remdesiviru, GS441524, ktorý cieli na enzým … Continue reading "Preklinický inhibítor GS441524 v kombinácii s GC376 účinne potláčal množenie SARS-CoV-2 v dýchacom trakte myší."\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.fipwarriors.eu\/en\/preklinicky-inhibitor-gs441524-v-kombinacii-s-gc376-ucinne-potlacal-mnozenie-sars-cov-2-v-dychacom-trakte-mysi\/\" \/>\n<meta property=\"og:site_name\" content=\"FIP Warriors CZ\/SK \u00ae\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/groups\/fipczsk\" \/>\n<meta property=\"article:published_time\" content=\"2020-11-13T19:49:41+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-29T07:50:22+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/01\/mers-virus-coronavirus-crop.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"989\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"L. M.\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"L. M.\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.fipwarriors.eu\\\/preklinicky-inhibitor-gs441524-v-kombinacii-s-gc376-ucinne-potlacal-mnozenie-sars-cov-2-v-dychacom-trakte-mysi\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.fipwarriors.eu\\\/preklinicky-inhibitor-gs441524-v-kombinacii-s-gc376-ucinne-potlacal-mnozenie-sars-cov-2-v-dychacom-trakte-mysi\\\/\"},\"author\":{\"name\":\"L. 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Abstrakt Bezprecedentná pandémia koronavírusovej choroby z roku 2019 (COVID-19) spôsobená vírusom ťažkého akútneho respiračného syndrómu druhého typu (SARS-CoV-2) predstavuje vážnu hrozbu pre verejné zdravie na celom svete. Naliehavo je potrebné vyvinúť účinné terapie proti SARS-CoV-2. Hodnotili sme antivírusovú aktivitu pôvodného nukleotidového analógu remdesiviru, GS441524, ktorý cieli na enzým … Continue reading "Preklinický inhibítor GS441524 v kombinácii s GC376 účinne potláčal množenie SARS-CoV-2 v dýchacom trakte myší."","og_url":"https:\/\/www.fipwarriors.eu\/en\/preklinicky-inhibitor-gs441524-v-kombinacii-s-gc376-ucinne-potlacal-mnozenie-sars-cov-2-v-dychacom-trakte-mysi\/","og_site_name":"FIP Warriors CZ\/SK \u00ae","article_publisher":"https:\/\/www.facebook.com\/groups\/fipczsk","article_published_time":"2020-11-13T19:49:41+00:00","article_modified_time":"2023-03-29T07:50:22+00:00","og_image":[{"width":1920,"height":989,"url":"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/01\/mers-virus-coronavirus-crop.jpg","type":"image\/jpeg"}],"author":"L. M.","twitter_card":"summary_large_image","twitter_misc":{"Written by":"L. 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M.","author_link":"https:\/\/www.fipwarriors.eu\/en\/author\/starman\/"},"uagb_comment_info":0,"uagb_excerpt":"Celý článok nájdete na serveri biorxiv.org; 13.11.2020. Abstrakt Bezprecedentná pandémia koronavírusovej choroby z roku 2019 (COVID-19) spôsobená vírusom ťažkého akútneho respiračného syndrómu druhého typu (SARS-CoV-2) predstavuje vážnu hrozbu pre verejné zdravie na celom svete. Naliehavo je potrebné vyvinúť účinné terapie proti SARS-CoV-2. Hodnotili sme antivírusovú aktivitu pôvodného nukleotidového analógu remdesiviru, GS441524, ktorý cieli na enzým…","_links":{"self":[{"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/posts\/3824","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/comments?post=3824"}],"version-history":[{"count":1,"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/posts\/3824\/revisions"}],"predecessor-version":[{"id":11743,"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/posts\/3824\/revisions\/11743"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/media\/3825"}],"wp:attachment":[{"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/media?parent=3824"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/categories?post=3824"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.fipwarriors.eu\/en\/wp-json\/wp\/v2\/tags?post=3824"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}