{"id":3830,"date":"2020-08-27T09:01:57","date_gmt":"2020-08-27T07:01:57","guid":{"rendered":"https:\/\/www.fipwarriors.eu\/?p=3830"},"modified":"2023-03-29T09:50:23","modified_gmt":"2023-03-29T07:50:23","slug":"klinicka-ucinnost-kombinovanej-liecby-itrakonazolom-a-prednizolonom-na-liecbu-ucinnej-macacej-infekcnej-peritonitidy","status":"publish","type":"post","link":"https:\/\/www.fipwarriors.eu\/en\/klinicka-ucinnost-kombinovanej-liecby-itrakonazolom-a-prednizolonom-na-liecbu-ucinnej-macacej-infekcnej-peritonitidy\/","title":{"rendered":"Clinical efficacy of itraconazole and prednisolone combination therapy in the treatment of feline infectious peritonitis"},"content":{"rendered":"<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Kameshima+S&amp;cauthor_id=32848107\">Satoshi Kameshima<\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Kimura+Y&amp;cauthor_id=32848107\">Yuya Kimura<\/a><sup>&nbsp;<\/sup>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Doki+T&amp;cauthor_id=32848107\">Tomoyoshi Doki<\/a><sup>&nbsp;<\/sup>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Takano+T&amp;cauthor_id=32848107\">Tomomi Takano<\/a><sup>&nbsp;<\/sup>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Park+CH&amp;cauthor_id=32848107\">Chun-Ho Park<\/a><sup>&nbsp;<\/sup>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Itoh+N&amp;cauthor_id=32848107\">Naoyuki Itoh<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\" id=\"full-view-identifiers\"><li>PMID:&nbsp;<strong>32848107<\/strong><\/li><li>PMCID:&nbsp;<a target=\"_blank\" rel=\"noreferrer noopener\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc7653327\/\">PMC7653327<\/a><\/li><li>DOI:&nbsp;<a target=\"_blank\" rel=\"noreferrer noopener\" href=\"https:\/\/doi.org\/10.1292\/jvms.20-0049\">10.1292\/jvms.20-0049<\/a><\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Origin&aacute;lny &#269;l&aacute;nok v <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7653327\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">National Library of Medicine<\/a>, 27.8.2020<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Abstrakt<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Do na&scaron;ej nemocnice pre mal&eacute; zvierat&aacute; bolo prinesen&eacute; 3-mesa&#269;n&eacute; ma&#269;iatko &scaron;k&oacute;tskej klapouchej ma&#269;ky s pleur&aacute;lnou tekutinou a n&iacute;zkym pomerom album&iacute;nu k globul&iacute;nu (pomer A\/G). Vzh&#318;adom na to, &#382;e v pleur&aacute;lnej tekutine bola zisten&aacute; <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemBody&gt;Ribonukleov&aacute; kyselina. Polymern&iacute; makromolekula, jej&iacute;&#382; z&aacute;kladn&iacute;mi stavebn&iacute;mi jednotkami jsou ribonukleotidy. Je sou&#269;&aacute;st&iacute; v&scaron;ech bun&#283;k a slou&#382;&iacute; k p&#345;enosu informac&iacute; z DNA d&aacute;le do bu&#328;ky. Existuje mnoho druh&#367; RNA s r&#367;zn&yacute;mi funkcemi. Mezi nejzn&aacute;mn&#283;j&scaron;&iacute; pat&#345;&iacute; mRNA (medi&aacute;torov&aacute;), tRNA (transferov&aacute;) a rRNA (ribozom&aacute;ln&iacute;).&lt;\/div&gt;\" href=\"https:\/\/www.fipwarriors.eu\/en\/glossary\/rna\/\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">RNA<\/a> ma&#269;acieho koronav&iacute;rusu typu I (FCoV), bola ma&#269;ke predbe&#382;ne diagnostikovan&aacute; ef&uacute;zna forma ma&#269;acej infek&#269;nej peritonit&iacute;dy (<a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemBody&gt;Infek&#269;n&aacute; peritonit&iacute;da ma&#269;iek (angl. Feline infectious peritonitis, zau&#382;&iacute;van&aacute; skratka FIP) je infek&#269;n&eacute; ochorenie ma&#269;iek sp&ocirc;sobuj&uacute;ce smr&#357;. N&aacute;zov je mierne zav&aacute;dzaj&uacute;ci, preto&#382;e nejde o z&aacute;pal pobru&scaron;nice (&#269;i&#382;e peritonea), ale o z&aacute;pal ciev (vaskulit&iacute;da). Klinick&eacute; pr&iacute;znaky FIP sa v&scaron;ak &#269;asto prejavuj&uacute; vo forme z&aacute;palu pobru&scaron;nice. V&iacute;rus FIP nap&aacute;da v&scaron;ak aj pohrudnicu &ndash; z toho d&ocirc;vodu je niekedy choroba ozna&#269;ovan&aacute; tie&#382; ako Infek&#269;n&aacute; ma&#269;acia polyserozit&iacute;da (Feline infectious polyserositis).&lt;\/div&gt;\" href=\"https:\/\/www.fipwarriors.eu\/en\/glossary\/fip\/\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">FIP<\/a>). Po podan&iacute; itrakonazolu a prednizol&oacute;nu sa pomer  A\/G zv&yacute;&scaron;il a pleur&aacute;lna tekutina takmer zmizla. Fek&aacute;lne hladiny FCoV sa do&#269;asne zn&iacute;&#382;ili. Ma&#269;ka v&scaron;ak za&#269;ala vykazova&#357; neurologick&eacute; sympt&oacute;my, a nakoniec sme kv&ocirc;li pretrv&aacute;vaj&uacute;cemu epileptick&eacute;mu stavu po 38 d&#328;och lie&#269;by museli prikro&#269;i&#357; k eutan&aacute;zii. Z&aacute;verom mo&#382;no ale poveda&#357;, &#382;e itrakonazol  vykazoval priazniv&yacute; &uacute;&#269;inok pri lie&#269;be ma&#269;ky s FIP. Je v&scaron;ak potrebn&eacute; &#271;al&scaron;ie sk&uacute;manie mo&#382;nej &uacute;lohy itrakonazolu pri lie&#269;be FIP.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>K&#318;&uacute;&#269;ov&eacute; slov&aacute;:<\/strong>&nbsp;infek&#269;n&aacute; peritonit&iacute;da ma&#269;iek;&nbsp;itrakonazol;&nbsp;neurologick&yacute; prejav;&nbsp;pleur&aacute;lna tekutina;&nbsp;ma&#269;ac&iacute; koronav&iacute;rus typu I.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Pozn&aacute;mka<\/strong>: Na slovenskom alebo &#269;eskom trhu obsahuj&uacute; itrakonazol napr&iacute;klad lieky s nazvom Conisor, Sporanox, Prokanazol. Pou&#382;&iacute;vaj&uacute; sa zvy&#269;ajne na lie&#269;bu ples&#328;ov&yacute;ch infekci&iacute;, napr. nechtov. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Predstavu o d&aacute;vkovan&iacute; u ma&#269;iek m&ocirc;&#382;ete z&iacute;ska&#357; v <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6339390\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Klinickej &scaron;t&uacute;dii o aplik&aacute;cii itrakonazolu na lie&#269;bu FCoV<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Satoshi Kameshima, Yuya Kimura, Tomoyoshi Doki, Tomomi Takano, Chun-Ho Park, Naoyuki Itoh. small animals A 3-month-old Scottish Fold kitten was brought in with pleural fluid and a low albumin-to-globulin ratio (A\/G ratio). Given that feline coronavirus RNA was detected in pleural fluid... <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.fipwarriors.eu\/en\/klinicka-ucinnost-kombinovanej-liecby-itrakonazolom-a-prednizolonom-na-liecbu-ucinnej-macacej-infekcnej-peritonitidy\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &quot;Clinical efficacy of combination therapy with itraconazole and prednisolone for the treatment of feline infectious peritonitis&quot;<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":3831,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","footnotes":""},"categories":[189,187],"tags":[],"class_list":["post-3830","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-abstrakt","category-odborne"],"featured_image_urls_v2":{"full":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/01\/conisor800px.png",800,528,false],"thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/01\/conisor800px-150x150.png",150,150,true],"medium":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/01\/conisor800px-300x198.png",300,198,true],"medium_large":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/01\/conisor800px-768x507.png",525,347,true],"large":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/01\/conisor800px.png",525,347,false],"1536x1536":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/01\/conisor800px.png",800,528,false],"2048x2048":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/01\/conisor800px.png",800,528,false],"trp-custom-language-flag":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/01\/conisor800px-16x12.png",16,12,true],"twentyseventeen-featured-image":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/01\/conisor800px.png",800,528,false],"twentyseventeen-thumbnail-avatar":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/01\/conisor800px-100x100.png",100,100,true],"woocommerce_thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/01\/conisor800px-250x250.png",250,250,true],"woocommerce_single":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/01\/conisor800px-350x231.png",350,231,true],"woocommerce_gallery_thumbnail":["https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/01\/conisor800px-100x100.png",100,100,true]},"post_excerpt_stackable_v2":"<p>Satoshi Kameshima,&nbsp;Yuya Kimura&nbsp;,&nbsp;Tomoyoshi Doki&nbsp;,&nbsp;Tomomi Takano&nbsp;,&nbsp;Chun-Ho Park&nbsp;,&nbsp;Naoyuki Itoh PMID:&nbsp;32848107PMCID:&nbsp;PMC7653327DOI:&nbsp;10.1292\/jvms.20-0049 Origin&aacute;lny &#269;l&aacute;nok v National Library of Medicine, 27.8.2020 Abstrakt Do na&scaron;ej nemocnice pre mal&eacute; zvierat&aacute; bolo prinesen&eacute; 3-mesa&#269;n&eacute; ma&#269;iatko &scaron;k&oacute;tskej klapouchej ma&#269;ky s pleur&aacute;lnou tekutinou a n&iacute;zkym pomerom album&iacute;nu k globul&iacute;nu (pomer A\/G). Vzh&#318;adom na to, &#382;e v pleur&aacute;lnej tekutine bola zisten&aacute; <a class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemBody&gt;Ribonukleov&aacute; kyselina. Polymern&iacute; makromolekula, jej&iacute;&#382; z&aacute;kladn&iacute;mi stavebn&iacute;mi jednotkami jsou ribonukleotidy. Je sou&#269;&aacute;st&iacute; v&scaron;ech bun&#283;k a slou&#382;&iacute; k p&#345;enosu informac&iacute; z DNA d&aacute;le do bu&#328;ky. Existuje mnoho druh&#367; RNA s r&#367;zn&yacute;mi funkcemi. Mezi nejzn&aacute;mn&#283;j&scaron;&iacute; pat&#345;&iacute; mRNA (medi&aacute;torov&aacute;), tRNA (transferov&aacute;) a rRNA (ribozom&aacute;ln&iacute;).&lt;\/div&gt;\" href=\"https:\/\/www.fipwarriors.eu\/en\/glossary\/rna\/\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">RNA<\/a> ma&#269;acieho koronav&iacute;rusu typu I (FCoV), bola ma&#269;ke predbe&#382;ne diagnostikovan&aacute; ef&uacute;zna forma ma&#269;acej infek&#269;nej peritonit&iacute;dy (FIP). Po podan&iacute; itrakonazolu a prednizol&oacute;nu sa pomer A\/G zv&yacute;&scaron;il a pleur&aacute;lna tekutina takmer zmizla. Fek&aacute;lne hladiny FCoV sa do&#269;asne zn&iacute;&#382;ili. Ma&#269;ka v&scaron;ak za&#269;ala vykazova&#357; neurologick&eacute; sympt&oacute;my, a nakoniec sme kv&ocirc;li pretrv&aacute;vaj&uacute;cemu epileptick&eacute;mu stavu po&hellip;<\/p>\n","category_list_v2":"<a href=\"https:\/\/www.fipwarriors.eu\/en\/category\/abstrakt\/\" rel=\"category tag\">Abstrakty<\/a>, <a href=\"https:\/\/www.fipwarriors.eu\/en\/category\/odborne\/\" rel=\"category tag\">Odborn\u00e9<\/a>","author_info_v2":{"name":"LM","url":"https:\/\/www.fipwarriors.eu\/en\/author\/starman\/"},"comments_num_v2":"0 comments","featured_image_src":"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/01\/conisor800px.png","author_info":{"display_name":"L. M.","author_link":"https:\/\/www.fipwarriors.eu\/en\/author\/starman\/"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Klinick\u00e1 \u00fa\u010dinnos\u0165 kombinovanej lie\u010dby itrakonazolom a prednizol\u00f3nom na lie\u010dbu ma\u010dacej infek\u010dnej peritonit\u00eddy - FIP Warriors CZ\/SK \u00ae<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.fipwarriors.eu\/en\/klinicka-ucinnost-kombinovanej-liecby-itrakonazolom-a-prednizolonom-na-liecbu-ucinnej-macacej-infekcnej-peritonitidy\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Klinick\u00e1 \u00fa\u010dinnos\u0165 kombinovanej lie\u010dby itrakonazolom a prednizol\u00f3nom na lie\u010dbu ma\u010dacej infek\u010dnej peritonit\u00eddy - FIP Warriors CZ\/SK \u00ae\" \/>\n<meta property=\"og:description\" content=\"Satoshi Kameshima,&nbsp;Yuya Kimura&nbsp;,&nbsp;Tomoyoshi Doki&nbsp;,&nbsp;Tomomi Takano&nbsp;,&nbsp;Chun-Ho Park&nbsp;,&nbsp;Naoyuki Itoh PMID:&nbsp;32848107 PMCID:&nbsp;PMC7653327 DOI:&nbsp;10.1292\/jvms.20-0049 Origin&aacute;lny &#269;l&aacute;nok v National Library of Medicine, 27.8.2020 Abstrakt Do na&scaron;ej nemocnice pre mal&eacute; zvierat&aacute; bolo prinesen&eacute; 3-mesa&#269;n&eacute; ma&#269;iatko &scaron;k&oacute;tskej klapouchej ma&#269;ky s pleur&aacute;lnou tekutinou a n&iacute;zkym pomerom album&iacute;nu k globul&iacute;nu (pomer A\/G). Vzh&#318;adom na to, &#382;e v pleur&aacute;lnej tekutine bola zisten&aacute; RNA ma&#269;acieho koronav&iacute;rusu &hellip; Continue reading &quot;Klinick&aacute; &uacute;&#269;innos&#357; kombinovanej lie&#269;by itrakonazolom a prednizol&oacute;nom na lie&#269;bu ma&#269;acej infek&#269;nej peritonit&iacute;dy&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.fipwarriors.eu\/en\/klinicka-ucinnost-kombinovanej-liecby-itrakonazolom-a-prednizolonom-na-liecbu-ucinnej-macacej-infekcnej-peritonitidy\/\" \/>\n<meta property=\"og:site_name\" content=\"FIP Warriors CZ\/SK \u00ae\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/groups\/fipczsk\" \/>\n<meta property=\"article:published_time\" content=\"2020-08-27T07:01:57+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-29T07:50:23+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.fipwarriors.eu\/wp-content\/uploads\/2021\/01\/conisor800px.png\" \/>\n\t<meta property=\"og:image:width\" content=\"800\" \/>\n\t<meta property=\"og:image:height\" content=\"528\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"L. 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