FAQ Group: General Questions

There is a reasonable assumption that GS-441524 in the small intestine has an absorption ceiling of about 10 mg / kg. For this reason, especially at higher doses, it is good to divide the total daily dose into 2 times a day.

The success rate of treatment is around 80%. It depends on the type of FIP, its degree, or when treatment started. There are also cases where the treatment did not work at all.

During treatment, it may happen that the cat also suffers from a secondary infection and may need ATB.

Safe ATBs:

• ATBs of penicilin type – Amoxicilin/Clavulanát (Clavaseptin, Clavamox, Noroclav, Xiclav, Synulox)
• Tetracyclines - Doxycycline (Ronaxan, Doxyhexal),
• Lincosamides – Clindamycin

Not recommended ATBs:

• Fluoroquinolones - They cross the blood-brain barrier and may cause neurological symptoms, therefore their use is not recommended: Baytril, EnrEnrofloxacin(Enroxil), Zeniquin, Marbofloxacin (Marbocyl), Pradofloxacin (Veraflox), Orbifloxacin (Orbax).
• Cephalosporines (Convenia)

dr. Pedersen believes that no supplements are necessary during GS treatment. However, due to experience with many treated cats, it is advisable to use hepatoprotectors (Liver, Hepapet, Zentonil etc...) and probiotics (e.g. Fortiflora), or to administer B12. But the basis is a good and meat-rich diet because of arginine, which cats cannot synthesize themselves.

It is not recommended.
Do not use Revolution, Stronghold, Frontline or other flea/tongs agents during FIP treatment. The most important factor in treatment is the environment. Vacuum every day (floors, wardrobes, bed linen, everything cats come in contact with) and wash all bed linen. Every day, comb the cat with a comb for fleas. You can prepare a mixture of water and apple cider vinegar (2: 1), which you apply to a cloth, and rub the cat daily. The flea solution repels. Although Revolution or Stronghold are relatively safe options, it is not clear whether there is an interaction between the active substance (selamectin) and GS441524 and whether the treatment process cannot be affected.

Not. It is not recommended. And it is not recommended even during posttreatment.

In some cases, the treatment will take place almost immediately, the cat's temperature will return to normal, he will start to be more active, he will start eating… Most cats will respond to the treatment within 2 days. With wet FIP, most of the fluid should normally be absorbed within 7-14 days. Either way, the therapeutic effect of any form of FIP in terms of improving the clinical condition, if you have the right dosage, you should notice a maximum of about 3-4 days. If this does not happen, it is time to think about changing the medicine or its form (eg from tablets to injections or vice versa) or increasing the dose. However, it is possible that the cat also suffers from another associated health problem that you will have to deal with with a veterinarian. FIP is often accompanied by other diseases and maybe your cat will need ATB, for example.

If the treatment does not work within 4 days, or even the cat's condition worsens, it is possible that it is not FIP at all and you should deal with this situation quickly. The danger of concentrating too much on FIP, even if the treatment does not seem to work, is that you may miss the real illness your cat is suffering from, and as a result may die just because you do not know about it and are not looking for it. If you have a dose of 12 mg / kg or higher, and the cat is not improving or deteriorating, it is almost certain that there is another serious problem than FIP.

Resistance to GS-441524 may also occur rarely, but is very rare during initial treatment and occurs rather in the form of partial resistance to relapse treatment, which can often be overcome by increasing the dose. Complete resistance requires treatment with another active substance, such as molnupiravir.

Injections are administered subcutaneously. Since the cat gets them 84 for the entire treatment period, you will alternate spots. Injections are given 24 hours apart. Ideally, your veterinarian would teach you injections. The injections are quite painful for the cat, so it is possible to get help from a family member.

The only known side effects are painful injection and possible skin lesions at the injection site. It should be noted that the cat receives 84 injections over 84 days.

The dose depends on the weight of the cat. However, the basic dosage is 6 mg GS per 1 kg live weight of a cat in wet and dry uncomplicated FIP. Ours is also available calculator:

Neurological and ocular forms require dosages of up to about 8-12 mg / kg. Be sure to consult a specific dosage.

If you like formulas, then calculating is simple.

i = m * d / c

i: injection dose [ml]
m: cat's weight [kg]
d: dosage of active substance (GS441524) for a given type of FIP [mg / kg]
c: concentration [mg/ml]

Example

Cat's weight is 2kg,
dose for your FIP type is 5mg/kg. 6mg / kg,
concentration of injection solution is 15mg / ml.

Enter into formula and you will get:

i = 2 * 6/15 = 0.8 ml